The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture

Multi-omics profiling coupled with SHAP analysis and molecular dynamics simulation identifies PIM1 as a therapeutic target in PET-MPs-associated gastric cancer

This study aimed to explore the molecular mechanisms underlying gastric cancer (GC) progression driven by polyethylene terephthalate microplastics (PET-MPs), and screen potential prognostic biomarkers for this specific type of GC. We established an integrated research pipeline co...

Mechanistic insights into VSIR-mediated AXL regulation and gastric cancer proliferation

Gastric cancer (GC) progression is frequently driven by complex tumor microenvironment signals. Here, our study identifies V-set immunoregulatory receptor (VSIR) as a key driver of GC progression via AXL regulation. High-throughput RNA sequencing demonstrated that VSIR overexpres...

Automatic segmentation of malignant pulmonary nodules on LUNA16 subsets using an attention-guided 3D U-Net framework

Objective Lung cancer is the leading cause of cancer-related mortality worldwide, and accurate segmentation of malignant pulmonary nodules is essential for quantitative lesion analysis and computer-aided lung cancer screening. Manual segmentation is time-consuming and highly depe...

TC-GAFnet: A Time-Aware Contrastive Grouped Attention Fusion Network with Empirical Priors for Adolescent Vision Prediction

Accurate prediction of spherical equivalent (SE) values is essential for early intervention in adolescent myopia management. Large-scale vision screening data provide valuable opportunities for longitudinal prediction; however, their utilization is challenged by sparse observatio...

Integration of ultrasound protrusion count and age for improved differentiation of BI-RADS 4A breast nodules

Objective To investigate the diagnostic value of the integration of the protrusion number on ultrasound images with age (using 40 years as the cutoff) in the differentiation of benign and malignant BI-RADS 4A breast nodules. Methods Retrospective analysis was conducted on BI-RADS...