The Catholic University of Korea Daejeon St. Mary's Hospital

Quantitative EEG Differences Across Two Sedation Conditions in a Child with Epilepsy: A Case Report

Background: Sedation is frequently required to obtain electroencephalography (EEG) recordings in children with neurodevelopmental disorders and structural etiologies of epilepsy. However, the extent to which different sedative agents influence quantitative interictal epileptiform...

Bicycle-Related Acetabular Fractures Are Associated with Anterior Column Involvement: A Multicenter Study with an Exploratory Analysis of Clipless Pedal Use

Background/Objectives: Cycling-related acetabular fractures have not been well described. We aimed to determine the proportion of acetabular fractures associated with bicycle accidents and to compare their fracture patterns with those caused by other mechanisms. Findings related...

Pathological calcium overload impairs skeletal muscle regeneration through sustained NFAT-dependent proliferative signaling

Abstract Skeletal muscle regeneration requires coordinated myoblast proliferation and differentiation. Calcium dysregulation is commonly observed in aging and disease-associated muscle weakness; however, its impact on myogenic progression remains unclear. In this study, we invest...

PCSK9 Inhibition Attenuates Renal Oxidative Stress and Lipotoxicity in Diabetic Kidney Disease in Association with AMPK Activation

Renal lipotoxicity and oxidative stress are major contributors to diabetic kidney disease (DKD), but the role of proprotein convertase subtilisin/kexin type 9 (PCSK9) and its relationship with AMP-activated protein kinase (AMPK) signaling remain unclear. We investigated the effec...

Genomic Reanalysis of Neurodevelopmental Disorders With and Without Epilepsy: Diagnostic Yield and Mechanisms of Newly Established Diagnoses

Background/Objectives: Genomic reanalysis may provide additional molecular diagnoses in patients with neurodevelopmental disorders (NDDs) whose initial genetic testing was nondiagnostic. We evaluated the diagnostic yield and mechanisms of newly established diagnoses in NDDs with...