The Affiliated Hospital to Changchun University of Chinese Medicine

Individualized multimodal pain management for chronic perineal pain

Rationale: Persistent perineal pain is a challenging clinical condition that may substantially impair sleep, urination, daily activities, and psychological well-being. Accurate assessment and individualized multimodal management are essential for improving symptom control and pat...

Modulation of Arachidonic Acid Metabolism by Pinoresinol Diglucoside Ameliorates Osteogenic Dysfunction via Coordinated NF ‐ κB Suppression and GSK3β /β‐Catenin Activation in Diabetic Osteoporosis

ABSTRACT Diabetic osteoporosis (DOP) is characterized by chronic low‐grade inflammation and impaired bone formation. Pinoresinol diglucoside (PDG), a bioactive compound derived from Eucommia ulmoides Oliv., has shown therapeutic potential in metabolic bone disorders; however, its...

Oxypaeoniflorin Attenuates Alcohol‐Associated Liver Disease, Potentially Involving TEAD4 ‐Mediated Inflammatory Signaling Cascades

ABSTRACT This study investigates the hepatoprotective effects and underlying molecular mechanisms of Oxypaeoniflorin (Opae) against alcohol‐associated liver disease (ALD). An in vivo ALD mouse model was established by chronic feeding of Lieber‐DeCarli EtOH‐containing liquid diets...

Endurance exercise and central fatigue

Background: Endurance exercise, characterized by sustained low-to-moderate intensity training, enhances physiological performance during prolonged physical activity and is widely used in sports training and the rehabilitation of chronic diseases. Central fatigue, a key issue in e...

Exploring the potential mechanism of Xiaoqinglong Decoction in the treatment of acute exacerbations of chronic obstructive pulmonary disease based on network pharmacology and in silico study

Xiaoqinglong Decoction (XQLD) is a traditional Chinese herbal formula widely used in clinical practice to treat acute exacerbations of chronic obstructive pulmonary disease (AECOPD) with notable efficacy. Studies indicate that XQLD can effectively modulate the inflammatory respon...

Estimated glucose disposal rate and incident cardiovascular disease across ageing cohorts in China, England, and the United States: cross-national consistency and transportability

The estimated glucose disposal rate (eGDR), an insulin-resistance surrogate derived from routine clinical variables, has been associated with cardiovascular disease (CVD). We examined its association with incident CVD, cross-national transportability, and incremental discriminati...