TH Köln - University of Applied Sciences

FIND: a phase-II study to evaluate the efficacy and safety of erdafitinib in FGFR-altered NSCLC

Abstract Introduction: FGFR alterations occur in approximately 2% of non-small cell lung cancer (NSCLC) patients, predominantly in squamous cell histology (sqNSCLC). We evaluated the efficacy of the selective FGFR1-4 inhibitor erdafitinib in patients with FGFR-altered NSCLC. Meth...

Random fitness landscapes are highly navigable

Abstract With the increasing availability of large-scale empirical fitness landscape data, there is a need for simple yet informative null models that can be used to interpret metrics of landscape ruggedness and navigability. A natural choice of a null model for highly rugged lan...

Gender and other diversity-related factors in psychiatric hospital care: protocol for the participatory mixed-methods PSY-DIVER study

Psychiatric hospital care is multimodal and typically comprises pharmacotherapy, psychotherapy, social therapy, occupational therapy, exercise therapy, and various forms of creative therapies. The use, acceptance and effectiveness of these interventions may be shaped by gender an...

Determinants of mutation susceptibility along the genome are largely invariant across human tissues

Abstract Background The propensity for accumulating somatic mutations varies along the genome, which critically influences somatic mosaicism, tumor evolution and the potential role of somatic mutations in the context of age-associated diseases. Genomic factors contributing to the...

Computed Retrieval, Decided Verdicts: A Parameter-Free Retrieval-to-Verification Chain over a Decidable Program Fragment

Technical report of the LNFdex(TM) engine: a retrieval-to-verification chain in which retrieval is computed (hash-derived 256-bit binary hypervectors, Hamming ranking, no learned parameters, no floats) and the verdict is decided (exhaustive verification over a 54-point decidable...

Computed Retrieval, Decided Verdicts: A Parameter-Free Retrieval-to-Verification Chain over a Decidable Program Fragment

Technical report of the LNFdex(TM) engine: a retrieval-to-verification chain in which retrieval is computed (hash-derived 256-bit binary hypervectors, Hamming ranking, no learned parameters, no floats) and the verdict is decided (exhaustive verification over a 54-point decidable...

Comparing End-of-Life carbon accounting methodologies reveals the need for standardization

Abstract This study provides a comparative assessment of existing methodologies and allocation approaches for quantifying End-of-Life (EoL) Greenhouse Gas (GHG) emissions in product life cycles, emphasizing the importance of harmonization and standardization in carbon accounting....

Outside Back Cover: Cycloazulenylene

Cycloazulenylene exhibits a remarkably narrow HOMO–LUMO gap, intense absorption in the visible range, and a unique tubular packing in the solid state. In Research Article e2204400, Tomáš Slanina, Oliver Dumele, and co-workers strained the nonalternant azulene, known for its anti-...