TH Köln - University of Applied Sciences

Determinants of mutation susceptibility along the genome are largely invariant across human tissues

Abstract Background The propensity for accumulating somatic mutations varies along the genome, which critically influences somatic mosaicism, tumor evolution and the potential role of somatic mutations in the context of age-associated diseases. Genomic factors contributing to the...

Computed Retrieval, Decided Verdicts: A Parameter-Free Retrieval-to-Verification Chain over a Decidable Program Fragment

Technical report of the LNFdex(TM) engine: a retrieval-to-verification chain in which retrieval is computed (hash-derived 256-bit binary hypervectors, Hamming ranking, no learned parameters, no floats) and the verdict is decided (exhaustive verification over a 54-point decidable...

Computed Retrieval, Decided Verdicts: A Parameter-Free Retrieval-to-Verification Chain over a Decidable Program Fragment

Technical report of the LNFdex(TM) engine: a retrieval-to-verification chain in which retrieval is computed (hash-derived 256-bit binary hypervectors, Hamming ranking, no learned parameters, no floats) and the verdict is decided (exhaustive verification over a 54-point decidable...

Comparing End-of-Life carbon accounting methodologies reveals the need for standardization

Abstract This study provides a comparative assessment of existing methodologies and allocation approaches for quantifying End-of-Life (EoL) Greenhouse Gas (GHG) emissions in product life cycles, emphasizing the importance of harmonization and standardization in carbon accounting....

Outside Back Cover: Cycloazulenylene

Cycloazulenylene exhibits a remarkably narrow HOMO–LUMO gap, intense absorption in the visible range, and a unique tubular packing in the solid state. In Research Article e2204400, Tomáš Slanina, Oliver Dumele, and co-workers strained the nonalternant azulene, known for its anti-...