Texas College

A proximity-driven and regioselective peptide bicyclization (PReP-Bicyc) approach for phage display libraries

Peptide macrocyclization is a powerful strategy to enhance the stability, rigidity, binding affinity, and cellular permeability of therapeutic candidates. Peptide bicycles provide superior conformational constraint but remain difficult to generate in phage-displayed libraries bec...

Integrating Insight and Uncertainty: Bayesian modeling for data-rich livestock systems

Abstract Bayesian statistical modeling provides a principled framework for integrating biological knowledge, process understanding, and observed data in animal science research. By treating all unobserved quantities as random variables and explicitly defining probability distribu...

Conceptus attachment coincides with initiation of an anti-inflammatory cytokine profile in the pig endometrium

Abstract Blastocyst implantation is associated with quasi-inflammatory reactions in the endometrium, which are resolved during the establishment of the definitive placenta. Quasi-inflammatory processes have also been documented in pregnant pigs, even though the blastocyst only at...

Repurposing Antipsychotic Agents in Oncology: Mechanistic Rationale, Emerging Evidence, and Therapeutic Potential

Antipsychotic agents—spanning first-, second-, and third-generation drug classes—are emerging as mechanistically diverse candidates for repurposing in oncology. Although developed to modulate dopaminergic and serotonergic neurotransmission, some of these compounds exert pleiotrop...

Deep Learning to Infer Ocean Dynamics

Inferring ocean dynamics remains challenging due to the complexity of multiscale nonlinear interactions, sparsity of observations, and limitations of numerical models. Deep learning (DL) has emerged as a powerful data-driven framework that exploits nonlinear dependencies across h...

Factors Associated with Undergraduate Students’ Engagement with Socioscientific Issues Misinformation and Disinformation

Abstract The rapid spread of socioscientific issues (SSI) misinformation and disinformation threatens civic engagement, poses serious environmental and public health risks, and undermines educational efforts toward scientific literacy. This is concerning for college students, who...

“Science is Not for You and Service is Not for Me”: a mixed methods study of epistemic exclusion in peer review

Heightened scrutiny in peer review of scholarship that challenges dominant perspectives has made it harder for scholars engaged in such work to contribute to advancing knowledge. In this study, we highlight how biases in the peer review process contribute to epistemic exclusion –...

Exposure to Family Violence and Adolescent Antisocial Behavior: Exploring the Differential Onset and Growth Rates of Mediational Impulsive Tendencies

INTRODUCTION: Adolescent externalizing symptoms, including aggression, impulsivity, and rule-breaking, are prevalent and often co-occur. Etiologically, developmental scientists have utilized developmental models to explain the link between exposure to family violence and adolesce...