Texas A&M Health Science Center

Conserved Core but Divergent Biochemical Features of RAS-MAPK Signalling in C. elegans

Genetic studies in Caenorhabditis elegans have established core principles of RAS-MAPK signalling. These nematodes encode three RAS proteins: LET-60/KRAS is essential for vulval induction, while RAS-1 and RAS-2 are orthologs of RRAS/RRAS2 and MRAS, respectively, but remain biolog...

RhoA Y42C drives cell plasticity and PD-1-mediated immune evasion of diffuse gastric cancer

Diffuse gastric cancer (DGC) is an aggressive gastric cancer subtype with a poor prognosis. The RHOA Y42C mutation is recurrent in DGC, but its independent oncogenic role is unclear. Next-Generation Sequencing of 431 DGC cases revealed that most RHOA mutations occurred without CD...

Childhood Obesity: An Update on Prevention, Evaluation, and the Expanding Treatment Landscape

Background Childhood obesity is a chronic, relapsing disease with significant short- and long-term cardiometabolic, psychosocial, and economic consequences. Over the past decade, advances in clinical research and updated professional guidelines have reshaped the evaluation, preve...