Texas A&M Health Science Center

A proximity-driven and regioselective peptide bicyclization (PReP-Bicyc) approach for phage display libraries

Peptide macrocyclization is a powerful strategy to enhance the stability, rigidity, binding affinity, and cellular permeability of therapeutic candidates. Peptide bicycles provide superior conformational constraint but remain difficult to generate in phage-displayed libraries bec...

Aerobic exercise induces selective changes in skeletal muscle protein quality control markers in rats with heart failure

The objective of this study was to determine whether aerobic exercise could aid in the preservation of the autophagy lysosomal system and mitigate oxidative stress in skeletal muscle during heart failure (HF) progression. Exercise tolerance was lower in HF groups compared to Cont...

Prenatal anxiety, tobacco use, and infant birth weight: a multilevel analysis of PRAMS data

Abstract Purpose Maternal anxiety is a clinically relevant mental health concern during pregnancy and may contribute to reduced fetal growth, particularly when co-occurring with prenatal tobacco use. To examine the individual and contextual associations of maternal anxiety and pr...

Divergent coronaviruses discovered in the virome of lamprey with reddening syndrome

ABSTRACT Lamprey reddening syndrome (LRS) is an emerging disease affecting pouched lamprey ( Geotria australis ; kanakana/piharau), a culturally and ecologically significant species in Aotearoa, New Zealand. Characterized by skin hemorrhaging and elevated mortality, the etiology...