Ted Rogers Centre for Heart Research

Identifying Cardiac Autoantibody Biomarkers that Predict the Severity of Chagas Cardiomyopathy

Chagas cardiomyopathy (ChCM) affects up to 30% of patients with chronic Chagas disease and lacks reliable biomarkers for severity and conduction abnormalities. We profiled cardiac autoantibodies using 2-dimensional gel electrophoresis and mass spectrometry, followed by enzyme-lin...

Shear Stress Regulates C-type Natriuretic Peptide Gene Expression by Valvular Endothelial Cells in a Sex-Dependent Manner

Abstract Aortic valve disease initiates on the fibrosa (aorta-facing) side of the valve leaflets, whereas the ventricularis side is disease-protected. Spatially predictable disease correlates with side-specific hemodynamics and gene expression: fibrosa-side valvular endothelial c...

Heterogeneity and ontogeny of mouse thymic macrophages reveal a requirement for Csf1r-expressing myeloid cells during early T cell development

Thymic macrophages (TMs) maintain tissue homeostasis by clearing the large numbers of apoptotic cells generated during T cell development, but how TM heterogeneity relates to their developmental origin and role in thymocyte maturation remains incompletely understood. Using comple...

Deploying Meaningful Medical Informatics and Artificial Intelligence Solutions in the Clinical Field: A Call to Action for Researchers in Cardio-Oncology Informatics

Abstract Rapid advances in oncology care have resulted in a growing population of cancer survivors, many of whom suffer from short- and long-term cancer therapy related cardiovascular toxicities (CTR-CVT). Cardio-oncology aims to diagnose and manage these cardiovascular condition...

The strategic impact of big data analytics and big data management on innovation, competitive advantage, and financial performance

Purpose This study aims to examine how big data analytics (BDA) capabilities – specifically the effective use of BDA tools and big data management (BDM) – affect the innovation process, competitive advantage and financial performance. Design/methodology/approach Drawing on the re...

The Family Job Hunt: The Influence of Family Member Active Job Search Behavior on Family–Work Conflict

ABSTRACT Existing research shows that family members may draw on work and personal resources to support job seekers. This research, however, explores the reverse: how the behaviors of job‐seeking family members may impact non‐job‐seekers' ability to manage work and life demands....

Pediatric Respiratory Failure and Support With Prolonged Extracorporeal Membrane Oxygenation: Multicenter Cohort Using the Extracorporeal Life Support Organization Registry, 1989–2021

OBJECTIVES: To characterize outcomes in children supported with 14 days or more of extracorporeal membrane oxygenation (ECMO) for respiratory indications. DESIGN: Retrospective analysis of the Extracorporeal Life Support Organization (ELSO) registry. SETTING: ECMO centers contrib...

Barriers and Facilitators in Using Personal Hearing Amplifiers from the Perspective of Healthcare Providers

Background: Hearing loss is experienced by two-thirds of hospitalized older adults and is associated with poor access to healthcare and negative health outcomes. Personal hearing amplifiers (PHAs) are evidence-based assistive devices provided in many hospitals to improve accessib...