Tanta University Hospital

Mesenchymal stem cells modulate pancreatic and splenic inflammation through PI3K/AKT/mTOR and TGF-β signalling in diabetic rats

Bone marrow-derived mesenchymal stem cells (MSC) can attenuate diabetic organ damage through immunomodulatory and paracrine mechanisms, yet the specific signalling pathways engaged in the pancreas and spleen remain poorly characterized. This study investigated the effects of a si...

Cryoneurolysis as an effective spasticity treatment option : a case series

Abstract Background Achieving effective treatment for spasticity remains a clinical challenge. The commonly used available options are either physical therapy ( stretching, electric stimulation, local heat or cold therapy), medical treatment either oral or injectable therapy even...

Diagnostic performance of T2 mapping and diffusion-weighted MRI in early detection of cartilage degeneration in knee osteoarthritis

Abstract Background Early knee osteoarthritis (OA) is associated with biochemical cartilage changes that may not be visible on conventional magnetic resonance imaging (MRI) or plain radiography. Quantitative MRI techniques, including T2 mapping and diffusion-weighted imaging (DWI...

Is methylphenidate truly cardiac-safe? Insight from biventricular speckle tracking echocardiography in pediatric patients with attention deficit hyperactivity disorder

Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental condition identified by inattention, hyperactivity, and impulsivity. ADHD pharmacotherapy, particularly methylphenidate (MPH), has raised concerns about its cardiovascular safety. We aimed to assess th...