Tang Du Hospital

Association of dexmedetomidine use with stroke-heart syndrome in critically ill patients with ischemic stroke: a MIMIC-IV study

Background Stroke-heart syndrome (SHS) is associated with poor outcomes after ischemic stroke (IS), but the relationship between dexmedetomidine (DEX) use and SHS remains unclear.Objective To evaluate the association between DEX use and SHS in critically ill patients with IS.Meth...

Advantage of cerebellar intermittent theta-burst stimulation in Alzheimer's disease (ACT-AD): study protocol for a multicenter, randomized, double-blind, sham-controlled trial

Abstract Introduction The cerebellum plays a crucial role in cognitive processing and thus presents a promising therapeutic target for Alzheimer’s disease (AD). This trial aims to evaluate the efficacy and safety of long-term, neuronavigated cerebellar intermittent theta burst st...

ZC3H13-Mediated m 6 A Modification of TRIM16 Suppresses EndMT and Atherosclerosis by Destabilizing Ang2 and Inhibiting the TLR4/NLRP3 Pathway

The RNA methyltransferase zinc finger CCCH-type containing protein 13 (ZC3H13) is downregulated in atherosclerosis (AS), but its functional mechanism remains unclear. Endothelial-mesenchymal transition (EndMT) is a core pathological driver of endothelial dysfunction in AS. This s...

Moldavoside ameliorates hypertension and autoantibodies targeting the angiotensin II type 1 receptor-induced endothelial damage via regulation of RhoE/CAV-1/eNOS axis

Globally, more than 100 million patients with resistant hypertension experience severe endothelial damage. Therefore, exploring the mechanisms underlying endothelial damage and developing effective interventions is urgently required. The clinical data and biochemical indicators o...

Fumarate Hydratase Lactylation Exacerbates Traumatic Brain Injury Pathology via Mitochondrial Dysfunction and Neuroinflammation

ABSTRACT Traumatic brain injury (TBI) induces brain tissue ischemia, hypoxia, and heightened glycolysis, leading to lactate accumulation. Lactate exerts multiple pathophysiological effects in the aftermath of TBI. This study aimed to elucidate the role of lactate‐mediated lactyla...

Salidroside ameliorates glucocorticoid-induced osteoporosis by regulating the PI3K/Akt/mTOR pathway: a network pharmacology and in vivo

Osteoporosis (OP) is a bone disorder, common cause of bone fracture and disability. Management of it needs development of an alternative medicine and present report evaluates the protective effect of salidroside against glucocorticoid induced osteoporosis in rat model. Network ph...

Self-regulated immune-neurovascular bone repair scaffold via functional surface features

Given specific microenvironment of bone repair, the novel implant endowed with self-regulated bone healing procedure was the representative trend of bio-functional decoration. Inspired by the microstructure and chemical composition of natural bone, bioactive calcium titanate coat...

Hydrogen-bonded organic framework-reinforced piezoelectric scaffolds for guided in situ bone regeneration

The fibrin network formed during the early bone repair establishes a viscoelastic micromechanical niche that recruits cells and releases cytokines, playing a pivotal role in primary callus formation. However, conventional metallic implants often lack these dynamic, bioactive cues...

Metabolic Syndrome in Adults with HIV on Antiretroviral Therapy: Risk Factors and a Predictive Model

Background: Metabolic syndrome (MetS) is common among people living with HIV, especially those receiving long-term antiretroviral therapy (ART). This study aimed to identify risk factors for MetS in adults with HIV receiving ART and to develop a predictive nomogram. Methods: This...

Tumor-intrinsic SIRPα drives anti-PD-1 resistance in esophageal cancer by coordinating proliferative dominance and T-cell exhaustion: A target for combinatorial immunotherapy

Signal regulatory protein alpha (SIRPα) is a novel immune checkpoint protein. However, the role and mechanism of SIRPα in esophageal cancer (ESCA) remain unclear. This study explores the role of tumor intrinsic SIRPα in ESCA. Twenty-one ESCA samples treated or not with anti-progr...

A Novel Photo-Responsive and Platelet-Compatible Strategy Based on Fe3O4-QCS-PEI-Cu and Aptamer for Targeted Inactivation of Bacterial Contaminants in Platelets

Bacterial contamination remains a critical safety concern in platelet transfusion, and there is an urgent demand for decontamination technologies that eliminate contaminating bacteria without damaging platelet viability and physiological function. Herein, Fe3O4-QCS-PEI-Cu-apt mic...

BAP31 Drives Cartilage Calcification through Disruption of Autophagosome–Lysosome Fusion in Osteoarthritis

Pathological cartilage calcification represents a pivotal pathological alteration in osteoarthritis (OA), yet its underlying mechanisms remain poorly understood. Exosomes are involved in facilitating calcification, and their biogenesis may be linked to autophagy disruption. Howev...

Novel customized 3D-printed prosthesis for complex infected bone defects: a clinical case series

Infected bone defects, especially irregular or long-segment defects, pose great clinical challenges. By performing bone defect reconstruction on patients with complex infected bone defects admitted to our hospital, this study explores the clinical efficacy of a novel customized 3...