Tanabe Research Laboratories

Calpain inhibition prevents high-glucose-induced autophagy blockade and mitochondrial fragmentation in endothelial cells and preserves vascular functions in diabetic mice

Endothelial dysfunction is a major contributor to diabetic vascular complications, yet the mechanisms linking hyperglycemia to impaired endothelial homeostasis remain insufficiently defined. This study identifies calpains as key regulators of endothelial autophagy and mitophagy u...

Safety and Effectiveness of Inebilizumab in Patients with Neuromyelitis Optica Spectrum Disorder: Interim Analysis of a Post-marketing Surveillance in Japan

Inebilizumab is used in Japan for relapse prevention in aquaporin-4 (AQP4) antibody-positive neuromyelitis optica spectrum disorder (NMOSD). Nationwide post-marketing surveillance (PMS) is underway to evaluate the real-world safety and effectiveness of inebilizumab in Japanese pa...

Integrating Chemistry and Biology: Evolving Design Principles Across Therapeutic Modalities

The authors declare no conflicts of interest. Data sharing not applicable to this article as no datasets were generated or analysed during the current study.

PhenoDEL: A NovelScreening Strategy Based on IntracellularProtein Degradation Activity

Abstract Targeted protein degradation (TPD), including proteolysis targeting chimeras (PROTACs) and molecular glue degraders (MGDs), is a promising therapeutic approach. However, systematic discovery of such small molecules remains a major challenge. Here, we present PhenoDEL, a...

Highlights from the 17th Japan Bioanalysis Forum Symposium

The 17th Japan Bioanalysis Forum Symposium was held in Himeji, Japan, in March 2026. Under the theme "Unlock Scientific Potential: Future of Bioanalytical Expert," the symposium provided a comprehensive forum to share and discuss the latest scientific, technological, and regulato...

Cross-disease immunological comparison reveals shared systemic immune activation across the broader spondyloarthritis spectrum

To perform cross-disease immunological comparison across the broader spondyloarthritis (SpA) spectrum and examine their association with disease activity. We analyzed 111 patients with active broader SpA spectrum (ankylosing spondylitis, inflammatory bowel disease–associated SpA,...