Tampere University Hospital

Assessing Behavioral and Environmental Facets of Obesity Unobtrusively Utilizing Digital Tools: Introducing the BETTER4U Indicators

ABSTRACT Understanding obesity involves evaluating numerous contributing factors. Collecting the necessary data for this can impose a significant burden on both research participants during clinical studies and real‐life deployments of digital tools aiding obesity management. The...

Automating clinical information retrieval from Finnish electronic health records using large language models

Abstract Clinicians often need to search for patient-specific information within electronic health records (EHRs) containing years of heterogeneous longitudinal documentation, a task that can be time-consuming, cognitively demanding, and prone to oversight. We evaluated 14 locall...

The clinical benefit of routine PET/CT imaging in asymptomatic head and neck squamous cell cancer patients one year post-treatment

BACKGROUND: The incidence of head and neck cancer is increasing, creating a growing need for follow-up strategies. The benefit of routine PET imaging beyond six months after treatment in asymptomatic patients remains unclear. OBJECTIVE: To assess whether routine PET/CT or PET/MRI...

Upfront surgery vs. neoadjuvant therapy in pancreatic cancer with venous involvement: a multicenter retrospective analysis

Abstract Introduction The benefits of neoadjuvant therapy (NAT) for pancreatic cancer (PC) with portal venous involvement remain debated. This study aimed to compare the short- and long-term outcomes of surgery with or without NAT in patients with PC with suspected venous involve...

Gut microbiome maturation in early childhood interacts with host genetics to predict type 1 diabetes risk

Prospective evidence linking early-life microbiome development and host genetics with type 1 diabetes (T1D) risk is limited. Here, we describe how gut microbiome maturation and host genetics influence T1D risk in the TEDDY study. We analysed 12,151 longitudinal metagenomes and ho...

Microbial differences and continuity across rectal, vaginal and endometrial sites in obese and normal-weight infertile women

Abstract Background This study characterizes microbial relationships and bacterial transfer across the rectal, vaginal and endometrial microbiomes upon embryo transfer, and evaluates the influence of obesity on site-specific profiles. The Tampere Infertility Microbiome Project (T...

Neuropathology of a patient with Parkinson's disease and biallelic expansion in RFC1

This is the first report of neuropathology in biallelic RFC1 expansion-associated Parkinson's disease (PD). It shows a synucleinopathy of intraneuronal Lewy bodies consistent with the clinical PD diagnosis while neuropathological CANVAS (Cerebellar Ataxia with Neuropathy and bila...

Connecting Skin and Gut in Dermatitis Herpetiformis: Insights from Gluten Challenge Transcriptomics

Dermatitis herpetiformis (DH) is a dietary gluten -induced autoimmune blistering skin disease. It is hypothesized to be initiated by a small intestinal mucosal immune response. Gluten-free diet (GFD) is the primary treatment for DHdermatitis herpetiformis and effectively resolves...

Concurrent emergency head and cervical spine CT utilization: temporal trends, diagnostic yield, and clinical implications

PURPOSE: To evaluate the diagnostic yield, temporal trends, and clinical implications of concurrent non-contrast head and cervical spine computed tomography (CT) in emergency department trauma patients over a 10-year period. METHODS: This single-center retrospective cohort study...

Cerebral glucose utilisation during musical emotions: A multimodal functional PET/MRI study:A multimodal functional PET/MRI study

Functional magnetic resonance imaging (fMRI) studies have demonstrated music-induced activation of the blood-oxygen-level-dependent (BOLD) signal across brain networks associated with auditory perception, motor control, and emotion. However, BOLD-fMRI reflects vascular responses...

Translation, cultural adaptation and psychometric validation of the Shoulder Pain and Disability Index into Finnish

Shoulder pain is a leading cause of disability, often resulting in functional limitations and reduced quality of life. Valid, culturally adapted patient-reported outcome measures (PROMs) are essential for assessing symptoms and treatment outcomes across populations. The Shoulder...

Diabetes mellitus and the risk of sudden cardiac death in patients with and without coronary artery disease

Abstract Background Diabetes is associated with sudden cardiac death (SCD), but evidence in patients without coronary artery disease (CAD) remains limited. SCD risk may vary by revascularisation strategy in diabetic patients with CAD. Methods We retrospectively analysed 22,395 co...

Expanding the cardiac phenotype of homozygous PPA2 variants: insights from a large Finnish family

Abstract Background Cardiomyopathies in children associate with significant morbidity and mortality. PPA2 deficiency is a rare mitochondrial disorder linked to sudden cardiac death in children and adolescents. Most reported cases are post-mortem, with limited data on surviving in...

Laparoscopic approach for emergency colon resection: a retrospective propensity score-matched study

Abstract Background Despite its routine use in elective procedures, the role of laparoscopy in emergency colorectal surgery remains debated due to limited evidence. This study compared laparoscopic and open surgery regarding complications, mortality, and hospital stay following e...

Long-term type 2 diabetes risk prediction using machine learning with childhood, adolescent, and genetic factors

Abstract Late diagnosis of type 2 diabetes increases patient morbidity and healthcare burden, yet current prediction models use adult risk factors to estimate 5–10-year risk. In this manuscript, we evaluate long-term prediction of type 2 diabetes over 38 years using childhood fac...