Tampere University Hospital

Diabetes mellitus and the risk of sudden cardiac death in patients with and without coronary artery disease

Abstract Background Diabetes is associated with sudden cardiac death (SCD), but evidence in patients without coronary artery disease (CAD) remains limited. SCD risk may vary by revascularisation strategy in diabetic patients with CAD. Methods We retrospectively analysed 22,395 co...

Expanding the cardiac phenotype of homozygous PPA2 variants: insights from a large Finnish family

Abstract Background Cardiomyopathies in children associate with significant morbidity and mortality. PPA2 deficiency is a rare mitochondrial disorder linked to sudden cardiac death in children and adolescents. Most reported cases are post-mortem, with limited data on surviving in...

Laparoscopic approach for emergency colon resection: a retrospective propensity score-matched study

Abstract Background Despite its routine use in elective procedures, the role of laparoscopy in emergency colorectal surgery remains debated due to limited evidence. This study compared laparoscopic and open surgery regarding complications, mortality, and hospital stay following e...

Long-term type 2 diabetes risk prediction using machine learning with childhood, adolescent, and genetic factors

Abstract Late diagnosis of type 2 diabetes increases patient morbidity and healthcare burden, yet current prediction models use adult risk factors to estimate 5–10-year risk. In this manuscript, we evaluate long-term prediction of type 2 diabetes over 38 years using childhood fac...