Takeda (Japan)

Power With Confounders in Clinical Trials Using External Controls

ABSTRACT When the number of patients is limited in clinical trials for rare diseases and pediatric developments, enrolling sufficient participants for confirmatory randomized clinical trials is difficult. Alternative trial designs using external controls have been proposed: augme...

Clear Cell Odontogenic Carcinoma of the Mandible Incidentally Detected During Routine Dental Examination: A Case Report With 8-Year Follow-up

Clear cell odontogenic carcinoma (CCOC) is a rare malignant odontogenic epithelial tumor that primarily affects the mandible. Due to its nonspecific clinical and radiographic features, preoperative diagnosis is often difficult. We report an asymptomatic case of CCOC in an elderly...

Assessing the consistency of overall survival extrapolations in Swedish health technology assessment reports of oncology treatments using extended follow-up data

BACKGROUND: Long-term overall survival (OS) extrapolations underpin cost-effectiveness appraisals, projecting survival beyond trial follow-up. We aimed to compare extrapolations presented in manufacturer submissions and appraisals published by the Swedish Dental and Pharmaceutica...

In Situ X-ray Scattering for Doxorubicin-Loaded Liposomes to Elucidate the Morphological Change Mechanism Depending on the Cooling Rate and Cholesterol Content

Abstract Doxorubicin (DOX)-loaded liposomes are one of the most established and clinically relevant nanomedicines in a drug delivery system. In this study, we elucidate the mechanistic relationships among cooling rate, lipid composition, and the resulting morphological evolution...

Highlights from the 17th Japan Bioanalysis Forum Symposium

The 17th Japan Bioanalysis Forum Symposium was held in Himeji, Japan, in March 2026. Under the theme "Unlock Scientific Potential: Future of Bioanalytical Expert," the symposium provided a comprehensive forum to share and discuss the latest scientific, technological, and regulato...