The Affiliated Taizhou People's Hospital of Nanjing Medical University

Triglyceride-Glucose Index and 10-Year Atherosclerotic Cardiovascular Disease Risk: Associations of Obesity-Related Indices in Two Nationally Representative Populations

BACKGROUND: The triglyceride-glucose (TyG) index has been associated with atherosclerotic cardiovascular disease (ASCVD) risk. However, the associations of TyG-related indices combined with obesity measures, including body mass index, waist circumference (WC), waist-to-height rat...

DC-CD8+ T cell-associated inflammation and sustained indel-derived candidate peptide exposure in radiation enteritis

Purpose Radiation enteritis (RE) is a frequent and challenging complication of radiotherapy for abdominal and pelvic malignancies, characterized by intestinal epithelial damage, immune dysregulation, and inflammation. Current treatments are limited by poor efficacy and significan...

miR-205-3p induces pyroptosis in triple-negative breast cancer by targeting HSP90AB1 and antagonizing MELK

Pyroptosis, a form of inflammatory programmed cell death, has emerged as a significant pathway in cancer biology, yet its regulatory mechanisms in triple-negative breast cancer (TNBC) remain incompletely understood. Integrated bioinformatics analysis of GEO datasets identified ke...

Macrophage-mimetic liposomal nanovesicles deliver CXCR2 antagonists to suppress CXCL2-driven breast cancer and atherosclerotic progression

The coexistence of breast cancer (BC) and atherosclerosis (AS) is increasingly recognized as an inflammation-driven comorbidity. This study identifies the CXCL2–CXCR2 signaling axis as a pivotal mechanistic link underlying both diseases and introduces a macrophage-mimetic nanopla...

Driver gene-based prognostic model benchmarked against machine learning survival models is associated with a CAF–TGFβ–EMT-like phenotype in hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is molecularly heterogeneous, limiting conventional prognostic tools. Whole-genome resequencing of six HCC cases was used only to filter candidates. Somatically mutated genes were intersected with HCC-annotated entries from five predefined driver re...

Hypertension knowledge, medication adherence, and BP control in community-dwelling hypertensive older adults: a cross-sectional study

Abstract Background Hypertension affects 31.6% of Chinese adults, yet medication nonadherence (30-50%) remains a critical barrier to control. The purpose of this study is to explore the relationship between hypertension knowledge, medication adherence, and lifestyle factors, and...

Water‐driven dispersible fiber electrode arrays for position‐dependent intracardiac electrophysiological recording

Abstract Intracardiac electrophysiological recording plays an essential role in identifying abnormal cardiac electrical activity and guiding arrhythmia diagnosis and treatment planning. A key challenge for minimally invasive intracardiac electrodes is to combine reliable transvas...

Surgical outcomes and prognostic factors in elderly Chinese patients with valvular heart disease: a multi-center retrospective cohort study

Abstract Objective To investigate surgical outcomes and prognostic factors in elderly patients (≥ 60 years) with valvular heart disease (VHD) undergoing surgery, and to provide evidence for optimizing clinical decision-making. Methods A retrospective analysis was conducted on 347...

Systemic Coagulation-Inflammation Index Predicts Functional Outcomes After Aneurysmal Subarachnoid Hemorrhage: Mediation by Delayed Cerebral Ischemia

The systemic coagulation-inflammation (SCI) index reflects both coagulopathic and inflammatory dynamics. We investigated its association with delayed cerebral ischemia (DCI) and functional outcome in aneurysmal subarachnoid hemorrhage (aSAH), explored the mediation effect of DCI...

Moderate aortic stenosis identified during intensive care admission for a non-cardiac primary diagnosis and 90-day mortality: a retrospective cohort study using the MIMIC-IV echocardiography database

Abstract Background Moderate aortic stenosis is associated with reduced survival in ambulatory cardiology populations, but its prognostic significance when identified during an intensive care admission for a non-cardiac primary diagnosis is unknown. We examined its association wi...

Comparative analysis of the CT and MRI features of pancreatic colloid carcinoma

To investigate the CT and MRI features of pancreatic colloid carcinoma (PCC) and to correlate imaging findings with histopathological characteristics. The CT and MRI images and clinical data of 15 patients with PCC confirmed by surgical resection and histopathological examination...

Calcium Phosphate Nanoparticle Delivery of siTRIB3 Inhibits EMT and Stemness in NSCLC

Background: TRIB3 is upregulated in non-small cell lung cancer (NSCLC) and associates with worse survival, yet targeted therapeutics remain lacking. Calcium phosphate (CaP) nanoparticles offer biocompatible, serum-stable delivery for siRNA therapy. Here, we developed CaP nanopart...

Nomogram for predicting the response of modified electroconvulsive therapy in patients with bipolar depressive episodes: a retrospective cohort study

Depressive episodes are a major manifestation of bipolar disorder, a common mental illness associated with substantial morbidity and premature mortality. Modified electroconvulsive therapy (MECT) is an effective physical treatment for bipolar depressive episodes. However, the cli...