Taizhou Central Hospital

The application potential of enzyme − induced calcium carbonate precipitation (EICP) in civil engineering: a systematic review

Enzyme-Induced Calcium Carbonate Precipitation (EICP) uses free or extracted enzymes to promote CaCO3 precipitation. The absence of intact microbial cells can reduce cell-related clogging and may improve access to fine pores in some materials. EICP therefore has potential for sea...

Association between coffee consumption and oral and pharyngeal cancers: a systematic review and meta-analysis

Oral and pharyngeal cancers are major contributors to global cancer-related morbidity and mortality, particularly in regions with high prevalence of tobacco, alcohol, and chewing-related exposures. Caffeine-containing beverages such as coffee and tea may influence carcinogenesis...

MSSAM: A robust multi-scale adaptation of Segment Anything Model for general medical image segmentation

Medical image segmentation aims to identify and segment key regions such as organs, lesions, and cancers, playing a crucial role in clinical diagnosis. Although the Segment Anything Model (SAM) has achieved excellent results in image segmentation, issues like complex human organ...

Multi-omics analysis deciphers tenocytes chromatin states and epigenetic regulation of tendon homeostasis

Tenocytes are the principal effector cells responsible for tendon homeostasis and repair, whose functions are governed by precise transcription programs. However, the epigenetic basis underlying the establishment and maintenance of their cellular identity, particularly the genome...

A programmed sequential organelle-targeted nanoattack strategy for cGAS-STING hyperactivation and potentiated systemic cancer immunotherapy

Cancer immunotherapy is hindered by insufficient immunogenic cell death (ICD) and suboptimal cGAS-STING activation. While organelle-targeted therapies hold promise, conventional treatments often fail because single-target attacks are neutralized by tumor buffering networks, where...

Osimertinib With or Without Chemotherapy in Advanced Non–Small Cell Lung Cancer With EGFR and Concurrent TP53 Mutations

Importance: Combination therapy has emerged as a promising therapeutic approach for patients with epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC). However, its clinical benefit-risk profile remains a focus of ongoing debate. Identifying patients...

Impact of carotenoids on body composition and adipokine hormones: a systematic review and meta-analysis of randomized controlled trials

Carotenoids, a class of antioxidant phytochemicals, have been proposed to influence adiposity and metabolic regulation through modulation of oxidative stress, inflammation, and adipokine secretion. However, clinical evidence remains inconsistent. This systematic review and meta-a...

Differentiating Chlamydia psittaci pneumonia from community-acquired pneumonia using clinical features and computed tomography findings

Chlamydia psittaci pneumonia (CPP) is a rare disease that is difficult to diagnose. Its clinical manifestations and chest imaging findings often overlap with those of other types of community-acquired pneumonia (CAP), and nonspecific treatment is likely to lead to rapid disease p...