Taipei Medical University-Shuang Ho Hospital

High-power spray coagulation as knife-based hemostasis improves procedural efficiency in colorectal underwater endoscopic submucosal dissection

Underwater endoscopic submucosal dissection (UESD) has emerged as a promising alternative to conventional techniques, offering advantages for colorectal neoplasms. However, intraoperative bleeding in the fluid field remains a major challenge, often disrupting procedural rhythm an...

Altered saccade control reveals executive dysfunction in late-life depression

Late-life depression (LLD) is frequently accompanied by executive dysfunction, which is associated with poorer clinical outcomes but remains difficult to assess objectively in older adults. Saccadic eye movements provide a rapid and non-invasive approach for probing executive-con...

Outcomes of Laser Interstitial Thermal Therapy-Augmented Surgery in the Management of Subcortical Glioblastoma.

BACKGROUND AND OBJECTIVES: Subcortical glioblastomas present surgical challenges owing to their proximity to critical anatomy. In this study, we assessed the utility of laser interstitial thermal therapy (LITT) in the management of subcortical glioblastomas. METHODS: Clinical out...

Identification of holistic needs in people with chronic kidney disease

PURPOSE OF REVIEW: Chronic kidney disease (CKD) is a growing global health challenge with substantial physical, psychological, social, and practical consequences beyond impaired kidney function. This review examines the rationale for holistic needs assessment, summarizes availabl...

SLC35D1 Is Associated with Colorectal Cancer Progression, EMT-Related Phenotypes, and Immune Infiltration

Colorectal cancer (CRC) is one of the most common malignancies worldwide, and the prognosis of patients with metastatic disease remains poor. Solute carrier proteins participate in diverse cellular processes, yet the biological and clinical relevance of the SLC35D family in CRC r...

Iliosacral Screw Fixation for Treating Sacral Fractures: A Modified Pedicle‐Guided Fixation Technique in Prone Position

ABSTRACT Background Sacral fractures are posterior pelvic ring injuries which mechanisms range from high‐energy trauma to low‐energy falls in osteoporotic patients. In surgical treatment, percutaneous approaches have demonstrated significant shorter operation time and less soft t...

Age-related clinical characteristics and treatment patterns in hospitalized orbital cellulitis: a real-world federated database study

Orbital cellulitis is an uncommon but potentially severe infection that can cause vision-threatening complications and death. Differences in clinical characteristics and management between pediatric and adult patients remain incompletely characterized at the population level. Thi...

Perioperative glucagon-like peptide-1 receptor agonist exposure and persistent postoperative opioid use among adults with type 2 diabetes mellitus: a propensity score-matched cohort study

Persistent postoperative opioid use remains an important perioperative concern, particularly in adults with type 2 diabetes, who may be more vulnerable to adverse postoperative recovery. Glucagon-like peptide-1 receptor agonists (GLP-1RAs) may influence postoperative recovery thr...

The potential impact of H1 antihistamines on clinical outcomes in NSCLC patients undergoing EGFR‐TKIs treatment

Background Epidermal growth factor receptor–tyrosine kinase inhibitors (EGFR‐TKIs) have substantially improved outcomes in non‐small cell lung cancer (NSCLC); however, the development of treatment resistance remains a major clinical challenge. This study examines the association...

A CD44-targeted PDA/ZnO redox-active nanocomposite that couples chemotherapy with mitochondrial stress and tumor immune remodeling

Bladder cancer therapy is frequently limited by inefficient drug retention and adaptive immune resistance within a hypoxic tumor microenvironment. Here, we report a CD44-targeted, fully synthetic nanocomposite (HPPZC) that converts chemotherapy into a mitochondria-associated ther...

Association of PR Interval with Illness Duration and Lymphocyte Count in Asian Adults with Bipolar Disorder

Objective: Individuals with serious mental illness are predisposed to a heightened risk of cardiac arrhythmias, with specific subtypes demonstrating a disproportionately high prevalence in Asian populations.An overlapping pathophysiology is hypothesized to underpin this clinical...

Enhancing nasal irrigation adherence through a multimodal health communication strategy: a phased improvement study

Abstract The adherence of chronic rhinitis patients to self-administered treatments is generally very low, which often presents a significant challenge in healthcare. The adherence of chronic rhinitis patients to regular nasal irrigation hygiene care is even lower. Therefore, in...

SGLT2 Inhibitors for Steatosis and Noninvasive Liver Markers in MASLD: A Meta-analysis of Randomized Trials

Abstract Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is closely linked to cardiometabolic dysfunction, yet liver-specific pharmacological options remain limited. Sodium-glucose cotransporter 2 (SGLT2) inhibitors have been proposed as potential the...

Safety and antiviral activity of inhaled siRNA SNS812 for treatment of mild-to-moderate COVID-19: a phase 2 randomized trial

Abstract Background SARS-CoV-2 remains a global health threat because ongoing viral evolution and immune evasion reduce the effectiveness of existing therapies. SNS812 is an inhaled small interfering RNA targeting a highly conserved region of the viral RNA-dependent RNA polymeras...

Development ofa Shapley Additive Explanations (SHAP)-InterpretableModel for Cardiovascular Risk Stratification in Type 2 Diabetes Mellitus:Implications of MDA-Modified Protein Adducts and Autoantibodies

Abstract Coronary artery disease (CAD) is the leading cause of mortality in type 2 diabetes mellitus (T2DM). This study explores the two-hit oxidative–immune hypothesis by evaluating malondialdehyde (MDA)-modified protein (MDA-protein) adducts and their corresponding autoantibodi...

Carbonyl stress promotes ferroptotic susceptibility through lipid metabolic remodeling in renal tubular epithelial cells

Diabetic kidney disease (DKD) is a leading cause of chronic kidney disease worldwide and is characterized by progressive tubular injury, oxidative stress, and metabolic dysregulation. Carbonyl stress, driven by the accumulation of reactive dicarbonyl metabolites such as methylgly...

Feasibility and Exploratory Outcomes of Foot‐Ankle and Walking Exercises for Diabetic Neuropathy, Stress, and Quality of Life: A Pilot Randomized Controlled Trial

Foot-ankle and walking exercises have been proposed as potential strategies for managing symptoms in people with diabetic peripheral neuropathy (DPN), yet evidence from primary care remains limited. This pilot study assessed the feasibility and acceptability of these intervention...

Tetraniline-Engineered Nickel Molecular Frameworks for Combinatorial NIR-Triggered Photothermal and Photodynamic Cancer Therapy

Near-infrared (NIR)-responsive nanomaterials are of critical importance for biomedical applications owing to their superior tissue penetration depths. Herein, we present a rational design of NIR-responsive tetraniline (TANI)-engineered nickel coordination frameworks for multimoda...

Flexible MultimodalNeural Probe with Integrated Three-ElectrodeAptameric Sensing for In Vivo Monitoring of DopamineDynamics and Neural Activity

Abstract Neural function emerges from the interplay between electrical activity and neurochemical signaling, yet most implantable neural interfaces primarily record electrophysiological signals and lack molecular specificity for neurotransmitter monitoring. Here, we developed a f...