Taipei Medical University Hospital

Soluble N-terminal EphA2 fragment as a diagnostic biomarker and functional mediator of tumor progression in triple-negative breast cancer

Triple-negative breast cancer (TNBC) lacks reliable biomarkers for early detection and remains a highly aggressive disease. Ephrin type-A receptor 2 (EphA2), a receptor tyrosine kinase frequently overexpressed in advanced cancers, undergoes MMP14-mediated cleavage that releases s...

High-power spray coagulation as knife-based hemostasis improves procedural efficiency in colorectal underwater endoscopic submucosal dissection

Underwater endoscopic submucosal dissection (UESD) has emerged as a promising alternative to conventional techniques, offering advantages for colorectal neoplasms. However, intraoperative bleeding in the fluid field remains a major challenge, often disrupting procedural rhythm an...

Altered saccade control reveals executive dysfunction in late-life depression

Late-life depression (LLD) is frequently accompanied by executive dysfunction, which is associated with poorer clinical outcomes but remains difficult to assess objectively in older adults. Saccadic eye movements provide a rapid and non-invasive approach for probing executive-con...

Glucagon-like peptide-1 receptor agonists are associated with an increased risk of repeat colonoscopy: a real-world retrospective cohort study

Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) suppress intestinal motility, raising concerns regarding impaired bowel preparation quality during colonoscopy. Given the widespread use of these agents and inconsistent societal guidelines regarding their peri-procedural mana...

Flipped learning for leader empowering leadership among nurse leaders in residential aged care facilities: a pilot cluster quasi-experimental study

Empowering leadership by nurse leaders is crucial for creating positive workplace environments. However, no previous studies have investigated the effects of educational interventions utilizing a flipped-learning approach to cultivate empowering leadership behaviors among nurse l...

SLC35D1 Is Associated with Colorectal Cancer Progression, EMT-Related Phenotypes, and Immune Infiltration

Colorectal cancer (CRC) is one of the most common malignancies worldwide, and the prognosis of patients with metastatic disease remains poor. Solute carrier proteins participate in diverse cellular processes, yet the biological and clinical relevance of the SLC35D family in CRC r...

Treatment-Free Interval as a Prognostic Factor for Survival Outcomes in Patients with Advanced or Recurrent Endometrial Cancer Treated with Pembrolizumab Plus Lenvatinib: A Multi-Institutional Real-World Cohort Study

Background/Objectives: The treatment-free interval (TFI) predicts benefit from platinum rechallenge in gynecological cancers, but its prognostic value in patients receiving second-line pembrolizumab plus lenvatinib for recurrent endometrial cancer (EC) is unknown. We evaluated wh...

Iliosacral Screw Fixation for Treating Sacral Fractures: A Modified Pedicle‐Guided Fixation Technique in Prone Position

ABSTRACT Background Sacral fractures are posterior pelvic ring injuries which mechanisms range from high‐energy trauma to low‐energy falls in osteoporotic patients. In surgical treatment, percutaneous approaches have demonstrated significant shorter operation time and less soft t...

Psychometric properties of the paternal breastfeeding self-efficacy scale-short form: a confirmatory factor analysis of fathers in Taiwan

Abstract Background Fathers’ confidence in supporting their partners’ breastfeeding is crucial for successful breastfeeding outcomes. The paternal version of the Breastfeeding Self-Efficacy Scale-Short Form (BSES-SF) is a globally recognised tool for measuring fathers’ perceived...

Subset-guided IL-15 expansion of NK cells amplifies antigen-specific CD4+ T cell immunity in melanoma

Abstract Background Natural killer (NK) cells comprise heterogeneous subsets with distinct developmental trajectories and effector functions; however, whether specific NK subsets can selectively coordinate adaptive antitumor immunity remains unclear. We identified a bone marrow-d...

Low-Supervision Asynchronously Monitored Home Rehabilitation for Adhesive Capsulitis: A Pilot Randomized Study

Background: Adhesive capsulitis often requires prolonged rehabilitation, and home exercise performed without supervision is difficult to document objectively. This pilot randomized trial evaluated the preliminary clinical effects and system-recorded engagement of a low-supervisio...

Bioactive Gold Plasmonic Interfaces Meet Artificial Intelligence: Advancing Saliva‐Based Surface‐Enhanced Raman Spectroscopy Diagnostics

Bioactive gold plasmonic nanostructures are enabling non-invasive saliva diagnostics by amplifying weak Raman signals and converting complex biofluid chemistry into information-rich spectral fingerprints. This Review examines saliva-based Raman and surface-enhanced Raman spectros...

Genome-wide association study of estimated glomerular filtration rate using repeated measurements in the Taiwan Biobank

Background: Chronic kidney disease (CKD) is a major global public health issue, with genetic factors playing a significant role in kidney function. Although genome-wide association studies (GWAS) have identified numerous loci associated with estimated glomerular filtration rate (...

The potential impact of H1 antihistamines on clinical outcomes in NSCLC patients undergoing EGFR‐TKIs treatment

Background Epidermal growth factor receptor–tyrosine kinase inhibitors (EGFR‐TKIs) have substantially improved outcomes in non‐small cell lung cancer (NSCLC); however, the development of treatment resistance remains a major clinical challenge. This study examines the association...

A CD44-targeted PDA/ZnO redox-active nanocomposite that couples chemotherapy with mitochondrial stress and tumor immune remodeling

Bladder cancer therapy is frequently limited by inefficient drug retention and adaptive immune resistance within a hypoxic tumor microenvironment. Here, we report a CD44-targeted, fully synthetic nanocomposite (HPPZC) that converts chemotherapy into a mitochondria-associated ther...

Association of PR Interval with Illness Duration and Lymphocyte Count in Asian Adults with Bipolar Disorder

Objective: Individuals with serious mental illness are predisposed to a heightened risk of cardiac arrhythmias, with specific subtypes demonstrating a disproportionately high prevalence in Asian populations.An overlapping pathophysiology is hypothesized to underpin this clinical...

Cilostazol Treatment for Intracerebral Hemorrhage: Targeting Dural Lymphatics

BACKGROUND: The meningeal lymphatic system contributes to hematoma resolution and neurological recovery after intracerebral hemorrhage (ICH). We previously demonstrated that intraperitoneal cilostazol administration promotes dural lymphatic growth and enhances clearance of intrac...

Allograft and Recycled Autograft Reconstruction Following Resection of Bone Due to Osteosarcoma: A Systematic Review of Time to Union and Complications

Abstract Background: Osteosarcoma is the most common primary malignant bone tumor, predominantly affecting the femur, tibia, and humerus. Despite advances in surgical oncology, comprehensive evaluations of biological reconstruction methods remain limited, with existing literature...

Necrotising enterocolitis triggers a TNF-driven gut-blood-brain cascade that disrupts the blood-brain barrier and induces TNFR1-skewed neuronal apoptosis and pyroptosis

Necrotising enterocolitis (NEC) in very-low-birthweight (VLBW) infants is associated with neurodevelopmental difficulties, but the mechanisms linking intestinal disease to brain injury remain unclear. We asked whether NEC propagates along a tumour necrosis factor alpha (TNF-α)-ce...

IgG Glycosylation Patterns May Identify Distinct Clinical Trajectories in Fibromyalgia Patients: A Longitudinal Pilot Study

ABSTRACT Background Altered immunoglobulin G (IgG) glycosylation was implicated in various conditions, but its role in fibromyalgia (FM) remains unclear. This study investigated IgG glycosylation patterns in FM patients and associations between glycosylation changes and clinical...