Taian City Central Hospital

Quercetin Ameliorates Cognitive Impairment in Obese Mice by Activating the PI3K/AKT/GSK3β Signaling Pathway via the Microbiota–Gut–Brain Axis

Abstract Obesity and its associated insulin resistance are important risk factors for cognitive impairment. In this study, a 10-week C57BL/6 mouse model was established to investigate the effects of dietary quercetin supplementation at 0.05% (w/w) on HFFD-induced obesity-related...

Water hardness and all-cause and cause-specific mortality: evidence from a prospective cohort study

The health implications of domestic water hardness remain controversial, with limited prospective evidence on cause-specific mortality. We investigated associations of calcium carbonate (CaCO 3 ), calcium (Ca), and magnesium (Mg) concentrations with all-cause and cause-specific m...

Urolithin A mitigates doxorubicin-induced myocardial injury via suppression of ROS-driven apoptotic signaling.

BACKGROUND: were investigated. METHODS: protective mechanism. RESULTS: . CONCLUSION: by inhibiting ROS-driven apoptosis, which yields significant insights for combating DOX-mediated myocardial injury.

Hostile microenvironment-driven oxygenator hydrogel with spatiotemporally feedback regulated hif-1α for accelerating diabetic wound healing

Diabetic wounds remain notoriously intractable due to a hostile microenvironment characterized by hyperglycemia, hypoxia, and oxidative stress. However, existing therapies often lack the ability to autonomously and sustainably remodel this pathological niche. Herein, a smart nano...