System Simulation (United Kingdom)

Comparison of pooled and Bayesian approaches for the analysis of paediatric pharmacokinetic data leveraging prior adult knowledge: A simulation case study for monoclonal antibodies against soluble targets

Aims Population pharmacokinetic (popPK) modelling is widely used to support paediatric dose optimization, yet consensus on appropriate modelling approaches remains limited. This study compared pooled and Bayesian popPK approaches for paediatric pharmacokinetics (PK) analysis usin...

Stochastic Analysis and Stability of Diabetic Population Dynamics

Modeling diabetic illness with random perturbations is the goal of this work. The proposed model consists of three classes: the pre-diabetic population, the diabetic population with complications, and the diabetic population without complications. We examined the suggested proble...

Engineering and land use intensified climate-driven Yangtze River flood hazards since the Little Ice Age

Understanding the interplay between climate variability and human activities is essential for assessing long-term river flood hazards. Yet, the relative contributions of natural and anthropogenic drivers to flood magnitude remain poorly constrained due to limited multicentury rec...