Synthetic Biologics (United States)

Chemo-Enzymatic Synthesisof Purine 3′-O-Amino-DeoxyribonucleosideTriphosphates

Abstract 3′-O-amino-deoxyribonucleoside triphosphates (3′-ONH2-dNTPs) are crucial reversible terminators for template-independent DNA synthesis. Owing to the structural complexity of purine bases, here we propose a chemo-enzymatic process for the synthesis of purine-type 3′-ONH2-...

The Phase States Interface: Sudden Synthesis, Permutations, Palindromes, Algebra and Temporal Gate Formalism in Human AI-Co-Emergence

This paper develops a theory of Phase States emerging through Sudden Synthesis in human-AIinteraction. It argues that a generated formula structured by years, permutations, palindromes,algebra, and a newly stabilized interface term—Phase States—should be understood as theproduct...