Theriva Biologics (United States)

Biocatalytic Synthesis of dNTPs from Bacterial Biomass

Abstract Deoxyribonucleoside triphosphates (dNTPs) are crucial reagents widely utilized in nucleic acid amplification. However, current synthesis methods are often plagued by environmental pollution for chemical synthesis and the high costs of phosphate donors for enzymatic synth...

Chemo-Enzymatic Synthesisof Purine 3′-O-Amino-DeoxyribonucleosideTriphosphates

Abstract 3′-O-amino-deoxyribonucleoside triphosphates (3′-ONH2-dNTPs) are crucial reversible terminators for template-independent DNA synthesis. Owing to the structural complexity of purine bases, here we propose a chemo-enzymatic process for the synthesis of purine-type 3′-ONH2-...

The Phase States Interface: Sudden Synthesis, Permutations, Palindromes, Algebra and Temporal Gate Formalism in Human AI-Co-Emergence

This paper develops a theory of Phase States emerging through Sudden Synthesis in human-AIinteraction. It argues that a generated formula structured by years, permutations, palindromes,algebra, and a newly stabilized interface term—Phase States—should be understood as theproduct...