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Thinking on maps: how foundation model agents explore, remember, and reason in map environments

Map environments provide a fundamental medium for representing spatial structure. Understanding how foundation model (FM) agents understand and act in such environments is therefore critical for enabling reliable map-based reasoning and applications. However, most existing evalua...

Chronic pain in Italy: exploring patient perspectives on care gaps and opportunities

Abstract Background : Chronic pain represents a significant public health burden, yet comprehensive data on patient perspectives in Italy remain limited. Despite Law 38/2010 guaranteeing access to pain therapy, gaps persist in understanding how patients experience care, navigate...

The sweet spot in protein design—Where deep learning meets first principles

This Perspective explores recent methods and prospective ideas for developing hybrid AI-physics-based pipelines for protein and antibody de novo design. We argue that the highest-confidence candidates emerge where deep learning and first-principles models agree, a "sweet spot" th...

Benchmarking strategic trade-offs: financial and sustainability performance in the Portuguese metal wholesale sector

Purpose This study aims to examine how firms manage competing performance objectives by analysing the trade-offs associated with financial structure, sustainability engagement and export activity. The study explores how strategic decisions intended to improve specific performance...