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The sweet spot in protein design—Where deep learning meets first principles

This Perspective explores recent methods and prospective ideas for developing hybrid AI-physics-based pipelines for protein and antibody de novo design. We argue that the highest-confidence candidates emerge where deep learning and first-principles models agree, a "sweet spot" th...

Benchmarking strategic trade-offs: financial and sustainability performance in the Portuguese metal wholesale sector

Purpose This study aims to examine how firms manage competing performance objectives by analysing the trade-offs associated with financial structure, sustainability engagement and export activity. The study explores how strategic decisions intended to improve specific performance...