Swiss Tropical and Public Health Institute

Integrating human rabies vaccines into routine immunization services in Tanzania: A participatory systems mapping study

Abstract Study aim : Human rabies is 100% preventable with post-exposure prophylaxis (PEP) administered immediately after exposure to a rabid animal. In low-income countries, access to PEP is hampered by challenges, including frequent vaccine stockouts, limited facilities providi...

One Health epidemiology of cystic echinococcosis in Bhutan: A hospital-based study with complementary abattoir surveillance data

Abstract Background : Cystic echinococcosis (CE) is a neglected zoonosis that disproportionately affects rural and economically disadvantaged populations worldwide. Although CE cases have been reported in Bhutan, epidemiology of CE remains unclear, and evidence integrating human...

Transient receptor potential channel activation targets multiple stages of the schistosome parasite

Schistosomiasis, a neglected tropical disease caused by infection with parasitic blood flukes of the genus Schistosoma , affects more than 250 million people worldwide. Currently, patients rely on a single medicine, praziquantel (PZQ), discovered half a century ago. To combat dru...

Associating Mycobacterium tuberculosis genomic variants with minimum inhibitory concentrations to delamanid and pretomanid

Emerging resistance to delamanid (DLM) and pretomanid (Pa) threatens drug-resistant tuberculosis (DR-TB) treatment outcomes. The lack of rapid molecular diagnostics, due to limited knowledge of resistance-conferring mutations, along with standardization challenges for critical co...

Occupational heat strain among home health care workers: a cross-sectional study

Abstract Background Extreme heat events affect workers’ health. Home health care workers face physically strenuous tasks, mobility demands, and increased workloads during heat events. Yet little is known about the extent of heat strain and the specific symptoms they experience. T...

Comparative cost analysis of community-based tuberculosis screening: Computer-Aided Detection (CAD) alone versus CAD with point-of-care C-reactive protein testing in South Africa and Lesotho

Community-based active case finding (ACF) for tuberculosis (TB) is recommended in high-burden settings, yet evidence on implementation costs from prospective programmatic data remains limited. We estimated and compared the costs of two community-based ACF screening approaches: Co...

Exploring heterogeneity in mosquito exposure and attraction and its implications for malaria transmission

Abstract Background Malaria transmission exhibits significant heterogeneity within communities, with small proportions of individuals experiencing disproportionate mosquito exposure. Methods This study addresses critical knowledge gaps in characterising and modelling this heterog...

Diagnostic performance of Baermann technique, urine-ELISA, stool-PCR and Strongyloides IgG4 rapid test for diagnosis of strongyloidiasis: a study protocol

Strongyloidiasis is caused by a parasitic worm, primarily Strongyloides stercoralis . In rural settings of Côte d’Ivoire, parasitological surveys have revealed that the prevalence of S. stercoralis infection can reach up to 50%. The World Health Organization has included S. sterc...

The value of mortality data to advance learning and decision-making dynamics in Mozambique’s health system

Abstract Introduction There is a lack of evidence on whether and how health systems stakeholders in Mozambique learn from routine health data. Despite the recurring claim by the stakeholders themselves that data in general should be the centre of informed public health policy, it...

Synthesis and Antiparasitic Activities of New Organometallic Derivatives of the Benzimidazole Anthelmintic Drugs

About 50 years after their development, the benzimidazole anthelmintic drugs still occupy a key role in the treatment of parasitic diseases. Like other anti-infective drugs, their extensive use has led to resistance development and now requires new solutions to treat these diseas...