Swiss Integrative Center for Human Health

Hypobaric hypoxia at 3,466 m suppresses hepatic bile acid metabolism and remodels the tumor lipidome in mice

Abstract Background Systemic hypoxia induces whole-body metabolic adaptation, but its impact on tumor metabolism and hepatic bile acid (BA) pathways remains poorly defined. Methods We investigated how high-altitude (HA) hypobaric hypoxia at 3,466 m affects tumor growth, tumor lip...

Post-heatwave immune challenge reshapes selection on heatwave responses

Abstract Climate change increases the frequency and intensity of heatwaves, yet predicting selection on heatwave-induced phenotypic responses is difficult because their fitness consequences may depend on subsequent environmental conditions. We experimentally tested how variation...

From exposure to evidence: The present and future of rodent surgical training in laboratory animal science

Surgical training remains one of the most consequential yet historically underexamined components of laboratory animal science (LAS). While advances in anesthesia, analgesia, asepsis, and oversight have improved welfare and scientific rigor, training has often relied on decentral...