Swiss Data Science Center

Computational deconvolution of drug sensitivity via single-cell–to–bulk transcriptome mapping

Analyses routinely conducted in both fundamental research and biomedical studies often report aggregate signals derived from heterogeneous mixtures of cells. These mixtures reflect the intrinsic anatomical and functional complexity of the tissues and organs from which they are de...

Determination of inter-individual differences in humeral head centre translations in subjects with healthy shoulders

Abstract The aims of this study were to (i) quantify glenohumeral (GH) joint translations in healthy shoulders, (ii) assess subject-specific variability in GH translations, (iii) determine whether bony joint geometry (glenoid height, width, retroversion, inclination, GH aspherici...

The lipidomic architecture of the mouse brain

Abstract Lipids are fundamental components of the brain, crucial for synaptic transmission and signal propagation. Altered brain lipid composition is associated with common and rare neuropathologies, yet the spatial organization of the mammalian brain lipidome remains insufficien...

Predicting calcification risk in prosthetic aortic valves: a hybrid physics-based and machine learning approach

Abstract Calcific degeneration remains the foremost failure mode of bioprosthetic aortic valves and a mounting concern for polymeric substitutes. Six prosthetic valve configurations, pairing two leaflet scallop geometries (V-shaped D1 V and U-shaped D2 U ) with three constitutive...