Suzhou Municipal Hospital

Multimodal analysis of sleep disturbances and heart disease in older adults: a machine learning and exploratory path analysis approach

Sleep disturbances and heart disease are common among older adults, yet the psychological and functional pathways linking sleep symptoms to heart disease remain insufficiently characterized. This study examined the association between sleep disturbance indicators and heart diseas...

Secondhand smoke exposure and fetal loss in nonsmoking pregnant women: a meta-analysis

Abstract Background Recent meta-analyses have reported inconsistent pooled relative risks of miscarriage associated with secondhand smoke exposure. Methods We conducted a meta-analysis to examine the relationship between fetal loss and maternal secondhand smoke exposure during pr...

Use of faricimab for refractory diabetic macular edema in real-world clinical practice: When anatomical success meets functional limits

Objective To evaluate the anatomical and functional outcomes of faricimab in the treatment of naïve and refractory diabetic macular edema (DME) and to investigate OCT biomarkers associated with visual outcomes. Methods This retrospective real-world study included eyes with DME tr...

Coronary plaque phenotypes, inflammation and cardiovascular prognosis in metabolic dysfunction-associated steatotic liver disease

Metabolic dysfunction-associated steatotic liver disease (MASLD) correlates with cardiovascular events. We sought to assess the association of coronary computed tomographic angiography (CCTA)-detected high-risk plaque characteristics (HRPC) and coronary inflammation with MASLD an...

Targeting Tc17 cell differentiation via the IL-6/JAK1/STAT3 signaling axis to attenuate immune checkpoint inhibitor-related colitis and promote tumor immunity

Immune checkpoint inhibitor-related colitis (IRC) is one of the most common immune-related adverse events, yet its underlying mechanisms remain unclear and treatments lack precision targeting. This study aims to elucidate the immune cell infiltration characteristics and regulator...

Integrated analysis of single-cell and transcriptome data reveals temporal dynamics of microglial phagocytic reprogramming in neuropathic pain progression

Abstract Neuropathic pain (NP) often progresses from acute to chronic, but the mechanisms driving this transition remain unclear. Microglia play a central role in spinal sensitization, yet their functional evolution during pain chronification is poorly understood. Through integra...

Efficacy and Safety of the First Adalimumab Biosimilar in Chinese Children with Severe Plaque Psoriasis: The PISCES Study, a Multicenter Prospective Study

Adalimumab, a monoclonal antibody targeting tumor necrosis factor-alpha, has been approved for the treatment of severe plaque psoriasis in children aged 4 years and older. Data on its use in the clinical management of pediatric psoriasis in China remains limited. This study is th...

Delayed diagnosis of intrauterine tuberculosis during mid-pregnancy leading to fetal loss and maternal disseminated tuberculosis: a case report and literature review

Atypical pregnancy symptoms lead to delayed diagnosis of tuberculosis (TB), resulting in serious harm to both the fetus and mother. We reported a patient with recurrent vaginal bleeding in mid-pregnancy accompanied by persistent low fever. Labor was induced after failed preservat...

Prevalence and clinical outcomes of malnutrition in hospitalized patients: a real-world study using a stepwise screening-assessment pathway

Hospital malnutrition is associated with adverse clinical outcomes, yet real-world evidence distinguishing nutritional risk screening from diagnostic assessment remains limited. This study evaluated a stepwise NRS2002-based screening and assessment pathway and examined associatio...