Suzhou Institute of Systems Medicine

Prostaglandin E2-mediated aging microenvironment fuels pathogenic fibrosis in cesarean section scar defect

Abstract With the increasing rates of cesarean section (CS), cesarean section scar defect (CSD) has become an escalating clinical concern due to uterine dysfunction and reduced fertility. However, the biological basis of CSD remains poorly understood, particularly the mechanisms...

Causal inference maps the sex-dimorphic genetic architecture and inflammatory-metabolic networks underpinning perceived aging in UK Biobank

Self-perceived facial aging is an externally observable aging-related phenotype that may reflect both biological and psychosocial dimensions of aging. However, its genetic and molecular determinants, sex-specific heterogeneity, and relationship with systemic aging-related pathway...

Macrophage RIPK3 facilitates TRAF6 K63-linked ubiquitination and exacerbates acute pancreatitis

Abstract Acute pancreatitis (AP) is characterized by acinar cell injury and death triggered by multiple etiologies, culminating in local and systemic inflammatory responses. Current therapeutic options for AP, particularly severe AP, remain limited. While RIPK3-mediated necroptos...

Prototype contrastive alignment with clinical attention enables multi-modal breast cancer molecular subtyping

Accurate molecular subtyping of breast cancer is essential for treatment planning, yet computational methods face challenges from class imbalance and variable-quality histopathology features. We propose a multi-modal framework that integrates histopathology image features with ge...