Suzhou Institute of Systems Medicine

Macrophage RIPK3 facilitates TRAF6 K63-linked ubiquitination and exacerbates acute pancreatitis

Abstract Acute pancreatitis (AP) is characterized by acinar cell injury and death triggered by multiple etiologies, culminating in local and systemic inflammatory responses. Current therapeutic options for AP, particularly severe AP, remain limited. While RIPK3-mediated necroptos...

Prototype contrastive alignment with clinical attention enables multi-modal breast cancer molecular subtyping

Accurate molecular subtyping of breast cancer is essential for treatment planning, yet computational methods face challenges from class imbalance and variable-quality histopathology features. We propose a multi-modal framework that integrates histopathology image features with ge...