Sutherland Hospital

Tracking CDK1 Dynamics With a Novel Biosensor Mouse and Clinical Cohorts to Predict CDK4/6 Inhibitor Sensitivity in ER+ Breast Cancer

ABSTRACT High‐risk estrogen receptor positive (ER+) early breast cancer (EBC) is managed with endocrine therapies and cyclin‐dependent kinase (CDK) 4/6 inhibitors, although no standard molecular markers clinically identify these tumors. CDK1 lies immediately downstream of CDK4/6...

The Complex Interplay of Duration of Residence and Region of Birth on Perinatal Outcomes Among Migrant Women in Australia: A Cohort Study

ABSTRACT Background Although migrants are recognised as heterogeneous, research often emphasises origin over receiving‐context experiences. Objectives We investigated maternal risk factors and perinatal outcomes by duration of residence in Australia, stratified by region of birth...

Extracellular vesicles in breast cancer metastasis: functional insights and advances in single-EV analysis

Abstract Breast cancer (BC) metastasis remains a leading cause of mortality despite significant advances in screening and diagnosis. Extracellular vesicles (EVs), secreted by all living cells, carry biologically active cargo such as RNAs and proteins, playing a crucial role in ce...