SUNY Upstate Medical University

Pharmacokinetic/pharmacodynamic evaluation of multidose oritavancin for prolonged durations of therapy

ABSTRACT Managing multidrug-resistant gram-positive infections is challenging, especially when prolonged therapy is needed for conditions like bacteremia, endocarditis, osteomyelitis, or other deep-seated infections. Oritavancin, a long-acting lipoglycopeptide, is increasingly us...

Cross-species single-nucleus transcriptomics identifies microglial Arhgap22 as a conserved modulator of synaptic phagocytosis and depression-related behaviors

Abstract Microglia-regulated neuroinflammation is associated with major depressive disorder (MDD), yet the molecular drivers of pathological microglia-neuron interactions remain poorly defined. Here, we conducted single-nucleus RNA sequencing (snRNA-seq) of the prefrontal cortex...

A standardized clinical algorithm for patient selection in cellular therapy across nineteen solid and hematological malignancies: An algorithm development study

ABSTRACT Background: Cellular therapies—chimeric antigen receptor T-cell (CAR-T), tumor-infiltrating lymphocyte (TIL), T-cell receptor (TCR)-engineered, gamma-delta (γδ) T-cell, and high-dose interleukin-2—have transformed the management of refractory malignancies. Over 6,000 int...

Comprehensive Psychometric Evaluation of the Child/Adult and Family Quality of Life Scale : Third Edition

PURPOSE: Quality of life (QoL) has become a key concept for understanding the impact of neurodevelopmental conditions and for monitoring intervention progress. Existing QoL measures often focus on health-related QoL in neurotypical populations or were developed specifically for a...

Major adverse cardiac events and mortality associated with ADHD and its treatment in adults with type 2 diabetes: a multi-national cohort study

Abstract Background Attention-deficit/hyperactivity disorder (ADHD) has been linked to elevated risk of type 2 diabetes (T2D). However, the impact of ADHD and ADHD medication use on prognosis and health outcomes in T2D remains unclear. This study investigates the associations of...

Safety and Efficacy of Left Atrial Ablation After Percutaneous Left Atrial Appendage Occlusion in High-Bleeding-Risk Patients with Atrial Fibrillation: A Multicenter Analysis from the PROCEED-AF Ablation Registry

BACKGROUND AND AIMS: Patients with left atrial appendage (LAAO) devices are increasingly referred for AF ablation, yet anticoagulation strategies remain uncertain. The goal of this study was to evaluate the safety and efficacy of catheter ablation for atrial fibrillation (AF) in...

Defining priorities for care among young adults diagnosed with breast cancer

Abstract Introduction Breast cancer is a leading cause of cancer‐related mortality among young adults (YAs) aged 18–39 years. Although the National Comprehensive Cancer Network recommends that YAs be treated at centers with age‐specific expertise, standardized care pathways are l...

DISENTANGLING TIGHTLY LINKED RISK AND RESILIENCE GENES IN ADHD

Research on the genetic and biological capacity to withstand risk for disease necessarily lags behind the discovery of reliable risk factors. Yet, as the reliability of ADHD-risk discoveries increases, so does the feasibility of ADHD-resilience research. Knowing how some people a...

PROFILING THE MOLECULAR STATE OF THE LIVING BRAIN IN SCHIZOPHRENIA AND ALZHEIMER'S DISEASE USING BRAINGENIE: THE BRAIN GENE EXPRESSION AND NETWORK IMPUTATION ENGINE

In 2005, Professor Ming T. Tsuang and his team published the first blood-based transcriptomic study of a psychiatric disorder in the journal he founded, Neuropsychiatric Genetics. In that pioneering work, Tsuang et al. established the validity of blood-based gene-expression profi...

Pooled Analysis of Valve‐in‐Valve and Valve‐in‐Ring Transcatheter Mitral Valve Replacement Using the SAPIEN Valve

Background Transcatheter mitral valve replacement (TMVR) using the Sapien (Edwards Lifesciences, Irvine, CA) transcatheter heart valve has become the preferred treatment for high‐risk patients with failed mitral bioprosthetic valves or prior surgical mitral valve repairs. Differe...

Mucosal Melanoma of the Nasal Cavity

Abstract Background: Mucosal melanoma is a rare variant of melanoma that is more aggressive than the more common cutaneous form. It often presents with nonspecific sinonasal symptoms, leading to delayed diagnosis. Involvement of the nasal cavity accounts for less than 1% of all m...

High-grade astrocytoma with piloid features: a clinical and genomic analysis of prognostic factors using a large cohort

BACKGROUND: High-grade astrocytoma with piloid features (HGAP) is a recently defined tumor type that is not well-understood. Prognostic factors of clinical outcomes are not well-established. METHODS: Methylation profiling was performed on tumor samples, many at the National Cance...

Gastrointestinal Bleeding Is Associated with Worse In-Hospital Outcomes in Patients with ST-Segment Elevation Myocardial Infarction: An Analysis of the National Inpatient Sample

Background/Objectives: Patients with ST-segment elevation myocardial infarction (STEMI) may develop gastrointestinal (GI) bleeding. We aimed to assess the impact of GI bleeding on in-hospital outcomes in patients with STEMI. Methods: This retrospective study was performed using t...

Conference Goals And Learning Preferences Among Attendees at A National Surgical Meeting

Objective This study evaluated differences in conference goals and preferred learning modalities across demographic groups at a national surgical conference. Design An optional online survey collected demographic information (gender, practice type, role, years in independent prac...

Perceived Importance of the Lifestyle Medicine Pillars on Wellbeing Among U.S. Adults: Prevalence and Sociodemographic Correlates

The objective of this study was to examine prevalence and sociodemographic correlates of perceived importance of different lifestyle medicine pillars for overall wellbeing among U.S. adults. We analyzed nationally representative cross-sectional data from the Pew Research Center’s...

Akhirin Preserves Hemostatic Wound Repair Through Non-Hematopoietic Regulation of the Vascular Injury Microenvironment

Hemostasis and wound healing are highly coordinated processes that involve rapid clot formation followed by controlled remodeling of the injured tissue microenvironment. Prior work on Akhirin (AKH), a secreted extracellular matrix protein containing two von Willebrand factor A do...

The YTHDF proteins modulate Alzheimer’s disease-associated brain gene signatures

Abstract Gene signatures of Alzheimer’s disease (AD) brains reflect the output of a complex interplay of genetic, epigenetic, epi-transcriptomic, and post-transcriptional regulations. To nominate candidate factors modulating these signatures, we developed a machine learning model...

Artificial intelligence in electrocardiogram interpretation for cardiovascular diagnosis and risk prediction: a systematic review of evidence through May 2026

Abstract Background Artificial intelligence-enabled electrocardiogram (ECG) analysis has expanded across cardiovascular diagnosis, monitoring, and risk prediction, but published studies vary in methodology, validation, and clinical applicability. We systematically reviewed AI app...

Pediatric Hospital Medicine Board-Certified and Non–Board-Certified Hospitalists Are Welcome Here

The Consortium of Pediatric Hospital Medicine, representing elected leaders in the field of Pediatric Hospital Medicine (PHM), proudly welcomes and fully supports every pediatric hospitalist, sub-board certified and non–sub-board certified alike, as integral contributors to our c...

Human‐operant evaluation of synthesized alternative reinforcement and resurgence

Basic research suggests that differential reinforcement with synthesized alternative reinforcement (i.e., delivery of two or more qualitatively different reinforcers contingent on a single alternative response) increases resurgence during disruptions to the contingency. We evalua...