Sunnybrook Research Institute

Variable Selection for the Propensity Score Model: Beyond Main Effects and Linear Relations

ABSTRACT Propensity score methods are frequently used to estimate treatment effects in observational studies. The propensity score is usually estimated using a logistic regression model with additive and linear effects. The limited literature on variable selection for the propens...

Heterogeneity and ontogeny of mouse thymic macrophages reveal a requirement for Csf1r-expressing myeloid cells during early T cell development

Thymic macrophages (TMs) maintain tissue homeostasis by clearing the large numbers of apoptotic cells generated during T cell development, but how TM heterogeneity relates to their developmental origin and role in thymocyte maturation remains incompletely understood. Using comple...

Blood proteomics of menopause map to brain aging and dementia risk

Abstract Menopause is a hallmark process in biological aging that has been implicated in later neurodegenerative risk, but the pathways underlying this connection remain unclear. Here we used blood proteomics data from several cohorts to identify biological changes associated wit...

The Impact of the Number and the Size of Clusters on Prediction Performance of the Stratified and the Conditional Shared Gamma Frailty Cox Proportional Hazards Models

ABSTRACT Researchers in biomedical research often analyze data that are subject to clustering. Development and validation of risk prediction models generally assumes independence of observations. For survival outcomes, the Cox proportional hazards (PH) regression model is commonl...

Readability and Quality of Online Patient Education Materials: Thyroid Radiofrequency Ablation

OBJECTIVE: To assess the readability and quality of online patient education materials regarding thyroid radiofrequency ablation. METHODS: Google searches were conducted using six search terms related to thyroid radiofrequency ablation, and the top 50 webpages from each search we...

Team-Based Outpatient Rheumatology Care: A Scoping Review of Terminology, Team Composition, and Impact on Advancing the Quintuple Aim

Objectives Team-based models of rheumatology care, in which rheumatologists and interdisciplinary healthcare professionals (IHPs) collaborate in care delivery, are increasingly recognized to improve outcomes across all domains of the Quintuple Aim (population health, patient expe...