Suizhou Central Hospital

Exonuclease 1 drives immune escape in lung adenocarcinoma by regulating the HIF-1α/PD-L1 axis

Lung Adenocarcinoma (LUAD) represents the most prevalent subtype of lung cancer and additionally possesses the highest potential for lethality. EXO1 is overexpressed in multiple cancers and linked to poor prognosis, but its role in LUAD immune regulation remains unclear. Immunosu...

Cortical hemodynamic dysregulation is linked to peripheral NIMETOX pathways in major depressive disorder: an 89-channel fNIRS systems-biology study.

Background: Major depressive disorder (MDD) is clinically heterogeneous, but relationships among cortical hemodynamic abnormalities, peripheral neuroimmune, metabolic, and oxidative stress (NIMETOX) processes, and clinical phenome features remain unclear. We applied a systems-bio...

Large-scale esophageal cancer screening through noncontrast computed tomography and artificial intelligence

The absence of accurate, noninvasive, scalable screening tools keeps early esophageal cancer (EC) detection a global health challenge. Although noncontrast computed tomography (NC CT) is widely accessible, the esophagus is a hollow tubular structure prone to collapse and motion a...

High‐Frequency Ultrasound Combined With Ultra‐Micro Angiography for Treatment Response Assessment in Papulopustular Rosacea

Data sharing not applicable to this article as no datasets were generated or analyzed during the current study.

CGA-DTA: interaction-conditioned graph topology and cross-graph attention for drug--target affinity prediction

Drug–target affinity (DTA) prediction supports virtual screening in computer-aided drug discovery, but graph-based models still face two linked limitations. Adaptive-topology methods usually learn drug and protein graphs independently and merge them only at the prediction head, w...

Molecular engineering of peptide-drug conjugates: strategies for enhancing precision oncology

Malignant neoplasms remain a formidable challenge to global public health, representing the second leading cause of mortality worldwide. While conventional small-molecule chemotherapeutics have historically served as a cornerstone of clinical oncology, their clinical utility is s...

Circulating and intraplaque interleukin-40 is associated with CTA-defined high-risk carotid plaques: an integrated imaging, serological, and histopathological study

Risk assessment of carotid atherosclerosis is moving beyond stenosis-based evaluation toward the identification of biologically active plaque phenotypes. Although CTA can characterize high-risk plaque morphology, biomarkers that reflect the inflammatory processes underlying these...

Perioperative non-invasive neuromodulation for delirium and cognitive recovery: from preclinical evidence to clinical translation

Perioperative neurocognitive disorders (PND) are a challenge for patients to accelerate postoperative recovery, and exploring more effective interventions can help reduce long-term cognitive dysfunction. Non-invasive neuromodulation (NIN) has shown potential in improving postoper...

Glycolipid metabolic crosstalk in tumor immune evasion and therapeutic targeting

Tumor immune evasion remains a major barrier to effective cancer immunotherapy and is closely associated with metabolic reprogramming. Glucose and lipid metabolism are highly interconnected processes that cooperatively reshape the tumor microenvironment (TME), regulate immune-cel...

Neoadjuvant Anbenitamab and HB1801 in ERBB2 -Positive Breast Cancer

IMPORTANCE The combination of neoadjuvant taxanes with trastuzumab and pertuzumab remains the cornerstone treatment strategy in ERBB2 -positive breast cancer. Anbenitamab (a ERBB2 -biparatopic antibody that induces profound receptor clustering) and HB1801 (a solvent-free albumin-...

Development and internal validation of a nomogram for predicting sepsis risk in neonates with pneumonia

To develop and internally validate an individualized model for predicting sepsis risk in neonates with pneumonia and to support early risk stratification at admission. Clinical records of 817 neonates with pneumonia admitted to the Department of Neonatology, Jiangsu Province (Suq...

Safety analysis of acyclovir use in neonates based on the FDA Adverse Event Reporting System

Acyclovir is the first-line treatment for neonatal herpes simplex virus infection; however, safety evidence in neonates remains limited. This study aimed to evaluate the safety profile of acyclovir in neonates using real-world pharmacovigilance data from the Food and Drug Adminis...

An explainable machine learning model based on quantitative HRCT parameters for identifying bronchoscopically confirmed airway stenosis in tracheobronchial tuberculosis

Airway stenosis is a frequent and serious complication of tracheobronchial tuberculosis (TBTB), leading to chronic airflow obstruction and reduced quality of life. However, no individualized predictive model currently exists to assess airway narrowing risk in these patients. This...

Molecular Networking-GuidedDiscovery of New Calbistrinsfrom Aspergillus japonicus and IntegratedOmics Analyses of Their Phytotoxic Mechanism

Abstract Fungal species are a rich source of bioactive metabolites for agrochemical discovery. LC-MS/MS-guided molecular networking of Aspergillus japonicus led to the isolation of eight rare calbistrin-type polyketides (1–8), including three new derivatives, japonidienes J–L (1–...

A distributed data governance architecture for smart cities based on data unified registration, dynamic catalog, and local LLM data coordination

Abstract Effective governance and secure sharing of data resources remain key challenges in smart-city development, where cross-department collaboration is constrained by data ownership boundaries and compliance requirements. This paper proposes a distributed data governance arch...

C-reactive protein–triglyceride glucose index for the detection of the severity of coronary artery disease in different glucose metabolic states in patients with H-type hypertension

Abstract Background The C-reactive protein–triglyceride glucose index (CTI) is a novel composite biomarker that integrates inflammation and insulin resistance. However, its association with the severity of coronary artery disease (CAD) in patients with H-type hypertension under d...

Research progress on multi-mechanism analysis and protection strategies of ovarian aging and fertility decline

Age-related fertility decline is an increasingly important challenge in reproductive medicine, driven largely by progressive ovarian aging. The aging ovary undergoes functional deterioration characterized by reduced ovarian reserve and declining oocyte quality, ultimately limitin...