Stowers Institute for Medical Research

High-resolution binding data of TFIID and cofactors show promoter-specific differences

Abstract TFIID is instrumental in recognizing promoter sequences and initiating transcription, yet a cohesive understanding of how this complex engages and functions at different promoter types in vivo is still lacking. Here, we employed ChIP-nexus to capture high-resolution bind...

Integrative Structural Modeling of Intrinsically Disordered Regions in a Human HDAC2 Chromatin Remodeling Complex

Abstract Histone deacetylase-containing complexes play central roles in chromatin regulation, yet the structural organization of their intrinsically disordered regions (IDRs) remains poorly understood. Here, we identify the previously uncharacterized protein C16orf87, which we re...

Rapidly evolving aphid gall effector proteins exhibit saposin-like folds

Abstract Many insects manipulate plants by injecting effector proteins. In one extreme example of this molecular “hijacking”, Hormaphis cornu aphids inject bicycle proteins into Hamamelis virginiana , contributing to the development of novel organs called galls. Bicycle proteins...

Condition dependent variation in bioactive metabolites of Bacillus siamensis during interaction with fungal pathogens

Interactions between antagonistic bacteria and fungal pathogens influence extracellular metabolite production and contribute to the efficacy of antagonistic agents (AGAs). However, comprehensive characterization of condition dependent metabolite variation during bacterial-fungal...