Stony Brook School

Pharmacokinetic-Modifying Linker Design Modulates Performance of Multivalent PSMA/GRPR-Cell-Targeting 177Lu Radiopharmaceuticals

Background/Objectives: A series of PSMA/GRPR-targeting compounds were selected based on modifications to their respective pharmacokinetic-modifying linking groups and the structure of the PSMA-binding moiety, to examine how these alterations impact binding affinity and specificit...

Developmental trajectories of tonic and phasic irritability from ages 12 to 21: early predictors, co‐development, and psychiatric outcomes in young adulthood

Background Irritability is a common and impairing, transdiagnostic feature of youth psychopathology. Theory distinguishes tonic irritability (persistent irritable mood) from phasic irritability (episodic temper outbursts), yet little is known about how these dimensions co‐develop...

Preemptive mechanical circulatory support in ventricular tachycardia ablation: A systematic review and meta-analysis

Abstract Background The benefit of preemptive mechanical circulatory support (MCS) for ventricular tachycardia (VT) ablation remains unclear. This meta-analysis compared the efficacy and safety of preemptive MCS to standard care for VT ablation. Methods An unrestricted literature...

Geographic diversity in the OBGYN residency match – longitudinal comparison during virtual interview and signaling cycles

It is not well known how recent changes to the residency match process have impacted geographic diversity among residency matches. This study uses the Obstetrics and Gynecology match to evaluate how the recent changes, such as starting virtual interviews and the implementation of...