Stony Brook Medicine

Preemptive mechanical circulatory support in ventricular tachycardia ablation: A systematic review and meta-analysis

Abstract Background The benefit of preemptive mechanical circulatory support (MCS) for ventricular tachycardia (VT) ablation remains unclear. This meta-analysis compared the efficacy and safety of preemptive MCS to standard care for VT ablation. Methods An unrestricted literature...

Why 30 mg Twice Daily Fails: Anti-Factor Xa Monitoring and the Persistent Dosing Gap in High-Risk Trauma Patients

Introduction Contemporary trauma guidelines support higher initial enoxaparin dosing for adult trauma patients, as standard dosing (30 mg twice daily [BID]) frequently fails to achieve target anticoagulant activity. While anti-factor Xa (anti-Xa) monitoring guides dose adjustment...

A compendium of next-generation patient-derived models for diverse cancers

Abstract The development of new therapeutics and the validation of pathogenetic cancer mechanisms require representative laboratory models 1,2 . However, existing collections represent only a fraction of the diversity observed in human cancer 2–4 . Recent technologies have enable...