Stomatological Hospital of Chongqing Medical University

The endothelial PECAM1–CXCR4 axis amplifies neutrophil degranulation to exacerbate sleep-deprived periodontitis: a systems-level framework for comorbidity therapy

Sleep deprivation (SD) is a known risk factor for periodontitis (PD), but the molecular bridge connecting this systemic stressor to local inflammation remains elusive. Here, through a systems-level investigation integrating human epidemiology, multi-omics, and disease modeling, w...

Age-related prognostic disparities in cutaneous melanoma: A population-based study and validated interactive web-based nomogram for individualized prognostic stratification

Background Cutaneous melanoma (CM) in older adults (≥65 years) has distinct clinicopathological features and poorer survival than in younger adults. We evaluated age-related cancer-specific survival (CSS), prognostic associations, and an interactive web-based nomogram. Methods We...