Stomatological Hospital of Chongqing Medical University

Development and validation of a predictive model for osteoporosis in middle-aged and older patients with type 2 diabetes mellitus: a multicenter retrospective study

The increasing prevalence of type 2 diabetes mellitus (T2DM) and osteoporosis (OP) among aging populations necessitates early OP risk identification. This study developed and validated a nomogram for predicting OP risk in middle-aged and older T2DM patients, and explored dose-res...

Machine‐Learning‐Guided DNAzyme Nanocages for Photoresponsive Immunomodulation and Spatiotemporal Control of Diabetic Bone Regeneration

ABSTRACT Inflammation poses a therapeutic paradox, as cytokine signals driving inflammatory disease can also provide transient repair cues. Effective intervention therefore requires selective suppression of pathogenic mediators and control over inhibition timing. RNA‐cleaving DNA...

The endothelial PECAM1–CXCR4 axis amplifies neutrophil degranulation to exacerbate sleep-deprived periodontitis: a systems-level framework for comorbidity therapy

Sleep deprivation (SD) is a known risk factor for periodontitis (PD), but the molecular bridge connecting this systemic stressor to local inflammation remains elusive. Here, through a systems-level investigation integrating human epidemiology, multi-omics, and disease modeling, w...

Age-related prognostic disparities in cutaneous melanoma: A population-based study and validated interactive web-based nomogram for individualized prognostic stratification

Background Cutaneous melanoma (CM) in older adults (≥65 years) has distinct clinicopathological features and poorer survival than in younger adults. We evaluated age-related cancer-specific survival (CSS), prognostic associations, and an interactive web-based nomogram. Methods We...