Stichting Epilepsie Instellingen Nederland

Oveporexton for Narcolepsy Type 1 — Results from Two Phase 3 Trials

BACKGROUND: Narcolepsy type 1 is characterized by excessive daytime sleepiness, cataplexy, disrupted sleep, sleep paralysis, and hypnagogic or hypnopompic hallucinations. Oveporexton (TAK-861), an oral orexin receptor 2-selective agonist, reduced symptoms of narcolepsy type 1 in...

Automated literature screening using large language models in headache research: a comparative performance evaluation of seven models using zero-shot and iterative prompt refinement

Abstract Background Large language models (LLMs) show promise for automating literature screening, although their performance varies across clinical domains and further evaluation is required for broader implementation. This study aimed to assess the accuracy, reliability and fea...