Steno Diabetes Centers

Demographic and clinical differences between individuals with and without DXA scans in Denmark

This study utilized two Danish registry-based cohorts to compare characteristics of DXA scanned individuals with not DXA scanned individuals. DXA scanned individuals had more comorbidities and used more medications, but there were signs of insufficient DXA scanning, particularly...

Long-term Trends in Upper Gastrointestinal Bleeding and Ischemic Outcomes after Myocardial Infarction

Abstract Aims Invasive management and intensive antithrombotic regimens have decreased ischemic risk after myocardial infarction (MI) at the cost of more bleeding. Of particular concern is upper gastrointestinal bleeding (UGIB), which is both common and preventable, yet not well...

Contemporary menopausal hormone therapy and thrombotic disease: nationwide nested case-control study

Abstract Objectives To investigate associations between current use of menopausal hormone therapy and development of venous thromboembolism, ischaemic stroke, and myocardial infarction. Design Nationwide nested case-control study. Setting National Danish health registries. Partic...

An International Position Statement on Practical Approaches for Inpatient Continuous Glucose Monitoring, Insulin Pumps, and Automated Insulin Delivery Systems in Adults

There is an urgent and unmet need for a practical clinical guideline addressing the use of continuous glucose monitoring (CGM), insulin pumps, and automated insulin delivery (AID) systems in hospital settings. The goal with this position statement is to facilitate effective and s...

An international position statement on practical approaches for inpatient continuous glucose monitoring, insulin pumps and automated insulin delivery systems in adults

There is an urgent and unmet need for a practical clinical guideline addressing the use of continuous glucose monitoring (CGM), insulin pumps and automated insulin delivery (AID) systems in hospital settings. The goal with this position statement is to facilitate effective and sa...

Household consumer purchases and chronic disease

Chronic disease risk stratification remains costly and often provides limited insight into modifiable exposures. Consumer purchases are routinely generated, low-burden measures of household lifestyle that can be linked to health outcomes with consent. In this Danish cohort study,...

Genome-wide analysis of social behaviour across social domains, reporters and developmental stages: a meta-regression approach

Abstract Social behaviour is a heritable trait linked to well-being and mental health, yet it varies across social context, including social domains, informants and development, which may shape its underlying genomic architecture. Here, we conducted a genome-wide meta-regression...

Sex and Socioeconomic Differences in the Initiation of SGLT2 Inhibitors and GLP ‐1 Receptor Agonists in Patients With Type 2 Diabetes and Cardiovascular Disease: A Nationwide Cohort Study

ABSTRACT Aims Cardioprotective glucose‐lowering drugs (GLDs) remain underutilised in individuals with Type 2 diabetes (T2D) and cardiovascular disease (CVD). We aimed to estimate the association between sex and socioeconomic status and initiation of cardioprotective GLDs and to i...

Distinct body mass index trajectories throughout childhood in girls with early puberty

Abstract Background Early pubertal development in girls has been associated with increased adiposity in childhood. However, longitudinal body mass index (BMI) trajectories preceding the diagnosis of precocious puberty (PP) or premature adrenarche (PA) are less well described. We...

Metoprolol in Chronic Obstructive Pulmonary Disease without Cardiovascular Disease

BACKGROUND: Beta-blockers may improve outcomes in patients with chronic obstructive pulmonary disease (COPD) without cardiovascular disease, but randomized trials have been inconclusive. METHODS: This was a multicenter, open-label, pragmatic, phase 4 randomized trial. Patients 40...

Intravenous Oxytocin Does Not Affect Glucose‐Regulating Hormones or Markers of Bone Turnover During Graded Glucose Infusion in Healthy Men

AIM: Oxytocin has been proposed to exert glucose-stabilising effects via modulation of pancreatic hormone secretion and to play a role in bone homeostasis. However, human data under controlled conditions are limited. We investigated the effects of intravenously infused oxytocin d...

Acute and Prolonged Effects of Sweeteners and Sweetness Enhancers on Postprandial Substrate Oxidation, Energy Expenditure, Glucose, and Insulin in Humans—A SWEET Sub-Study

Background/Objectives: Sweeteners and sweetness enhancers (S&SEs) have been proposed to impair energy metabolism acutely and over time. Methods: This sub-study investigated the acute effects of a mixture of acesulfame potassium and cyclamate (Ace-K/Cyc) versus water on postprandi...

Durability of RSV Prefusion F Vaccine Protection across Two RSV Seasons

BACKGROUND: Respiratory syncytial virus (RSV) is an important cause of hospitalization and death among older adults. Although first-season vaccine effectiveness against RSV-related hospitalization has been demonstrated for the bivalent RSV prefusion F protein-based vaccine (RSVpr...

Bivalent RSV Prefusion F Vaccine to Prevent Hospitalizations in Adults

BACKGROUND: Respiratory syncytial virus (RSV) is an important cause of severe respiratory disease in adults, with the highest burden among older adults and individuals with chronic health conditions. The bivalent RSV prefusion F (RSVpreF) vaccine has been shown to prevent RSV-ass...

From Roller Coaster to Confidence: A Qualitative Study of a Hybrid Exercise Program for Individuals With Type 1 Diabetes

OBJECTIVE This study aimed to explore the experiences and reflections of adults with type 1 diabetes (T1D) 3–24 months after completing a 15-week hybrid exercise program combining in-person and virtual components. Particular attention was given to how participants translated prog...

The effect of telemonitoring on quality of life in people with insulin‐treated type 2 diabetes: A secondary analysis of a randomised controlled trial

Abstract Aims Telemonitoring in type 2 diabetes (T2D) care has demonstrated positive trends in terms of glycaemic control. However, evidence regarding its impact on patient‐reported outcomes, such as general and diabetes‐specific quality of life (QoL), remains inconclusive. In pa...

Archival records of decisions made about tools or processes used in the Seedcase Project

This contains files related to decisions we've made for processes, workflows, tools, and services. They follow the style of 'architectural decision records. See our website at https://decisions.seedcase-project.org for more information.

Strengthening the engagement of mass media stakeholders in community-based health promotion interventions - the Danish Project SoL

<title>Abstract</title> <bold>Background</bold>: The potential positive effects of mass media stakeholders in health promotion have long been recognized. Health promotion interventions may benefit from exposure in mass media by attracting public attention and political support. M...

Prevalence, Incidence and Mortality of Chronic Kidney Disease in Type 1 and Type 2 Diabetes—A Nationwide Danish Register‐Based Cohort Study

ABSTRACT Aims Chronic kidney disease (CKD) remains a leading complication of diabetes, and understanding population‐level trends is crucial for prevention and healthcare planning. We examined national trends in CKD prevalence, incidence, and mortality among people with diabetes....

Patients’ experiences of living with the risk of Alzheimer’s disease – a multicentre qualitative study

Aims and objectives To explore the experiences of receiving and living with a diagnosis of prodromal Alzheimer’s disease. Background Alzheimer’s disease is a progressive dementia disorder, with pathology potentially developing years before clinical symptoms. Evidence concerning p...