Statistical Service

Adverse childhood experiences and autism spectrum disorder: a retrospective cohort study among late adolescents

Objective To examine the association between Adverse Childhood Experiences (ACEs) and Autism Spectrum Disorder (ASD) identification among Israel Defense Forces (IDF) personnel, focusing on predictors of ASD identification during military service.Methods A retrospective cohort stu...

Causality-integrated graph learning for multi-endpoint toxicity prediction

Toxicity prediction remains a longstanding challenge in the safety assessment of numerous artificial chemicals. While conventional single-endpoint models are effective for predicting many molecular properties, they fail to capture the complex mechanisms underlying toxicity, which...

Adverse Childhood Experiences and New-Onset of PTSD During Military Service.

INTRODUCTION: Exposure to adverse childhood experiences (ACEs) has been increasingly recognized as a potential risk factor for later psychopathology; however, its role in the development of post-traumatic stress disorder (PTSD) during military service remains insufficiently chara...

Local control of RCC pancreatic metastases is obtained by angiogenesis inhibitors

Background Metastatic clear-cell renal cell carcinoma (m-ccRCC) with pancreatic and/or thyroid metastases (PM/TM) is sensitive to vascular endothelial growth factor receptor tyrosine kinase inhibitors (VEGFR-TKIs). Optimal first-line therapy for these patients (VEGFR-TKI-monother...

Macroeconomic effects of progressive tax reform in Nigeria using synthetic control counterfactual and simulation analysis

Abstract This study examines the relationship between taxation structure and macroeconomic performance within a comparative panel of Nigeria, South Africa, the United Kingdom, and Canada over the period 2000–2024, while providing a forward-looking evaluation of Nigeria’s 2026 pro...

Degrees‐of‐Freedom Approximations for Conditional‐Mean Inference in Random‐Lot Stability Analysis

ABSTRACT Linear mixed models are widely used for pharmaceutical stability trending when sufficient lots are available. Expiry support is often based on whether lot‐specific conditional‐mean confidence limits remain within specification through a proposed expiry, and these limits...

Approximately optimal search on a higher-dimensional sliding puzzle

Abstract Higher-dimensional sliding puzzles are constructed on the vertices of a d -dimensional hypercube, where $$2^d-l$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mrow> <mml:msup> <mml:mn>2</mml:mn> <mml:mi>d</mml:mi> </mml:msup> <mml:mo>-</mml:mo> <mml:mi>...