Statistical Research (United States)

Causality-integrated graph learning for multi-endpoint toxicity prediction

Toxicity prediction remains a longstanding challenge in the safety assessment of numerous artificial chemicals. While conventional single-endpoint models are effective for predicting many molecular properties, they fail to capture the complex mechanisms underlying toxicity, which...

Family Mealtimes in Hispanic Households: Associations of General Parenting Styles and Food Parenting Practices with Adolescent Food Group Intake

Background/Objectives: Hispanic adolescents experience disproportionately high rates of obesity and diet-related health risks, yet the family and parenting factors that shape their dietary behaviors remain incompletely understood. This study examined associations between parent s...

A Polynomial Improvement for the Odd Cycle–Complete Ramsey Numbers

Abstract We give a polynomial improvement to the cycle-complete Ramsey numbers $$\begin{aligned} r(C_{\ell },K_k) \geqslant k^{1+\frac{1}{\ell -2} + \varepsilon _{\ell } + o(1)}, \end{aligned}$$ r ( C ℓ , K k ) ⩾ k 1 + 1 ℓ - 2 + ε ℓ + o ( 1 ) , for all fixed odd $$\ell > 7$$ ℓ >...

Quantifying immunosuppressive barriers using a mathematical framework of tumor-associated myeloid cell mediated resistance in oncolytic virotherapy

Oncolytic virotherapy (OVT) represents a promising frontier in oncology, utilizing engineered viruses to selectively lyse malignant tumor cells while simultaneously triggering a systemic anti-tumor immune response. However, the therapeutic efficacy of OVT is frequently hampered b...

Interfacial Properties of MoS2 Thin Films Grown on Functional Substrates

Abstract Interface chemistry and defect formation in MoS2 thin films grown on single crystal substrates critically determine the electronic structure of MoS2 and thus can strongly modify material functionality relevant for many applications, including electronics, optoelectronics...

Macroeconomic effects of progressive tax reform in Nigeria using synthetic control counterfactual and simulation analysis

Abstract This study examines the relationship between taxation structure and macroeconomic performance within a comparative panel of Nigeria, South Africa, the United Kingdom, and Canada over the period 2000–2024, while providing a forward-looking evaluation of Nigeria’s 2026 pro...

Degrees‐of‐Freedom Approximations for Conditional‐Mean Inference in Random‐Lot Stability Analysis

ABSTRACT Linear mixed models are widely used for pharmaceutical stability trending when sufficient lots are available. Expiry support is often based on whether lot‐specific conditional‐mean confidence limits remain within specification through a proposed expiry, and these limits...

Pollutant-induced changes in fish pigmentation and spatial patterns

Abstract Pigmentation abnormalities, ranging from hypo- to hyperpigmentation, can serve as biomarkers of developmental disruption in fish exposed to environmental contaminants. However, the mechanistic pathways underlying these alterations remain poorly understood. Studies have s...

Association of high birth weight with risk of early-onset colorectal cancer

BACKGROUND: Early-onset colorectal cancer (eoCRC), particularly rectal cancer, is increasing. We evaluated the association between high birth weight and eoCRC in a nested case-control study. METHODS: We included patients aged 15-49 years diagnosed with colorectal adenocarcinoma a...

Clinical Validation of a Point-of-Care Whole Blood Coagulometer in Patients on Factor Xa Inhibitors

Currently, no sensitive, widely available, rapid turnaround assays to measure the effect on coagulation of direct oral anticoagulants exist. The point-of-care ClotChek (Perosphere Technologies Inc.) coagulometer was developed to address this unmet need with high sensitivity and p...