Statens Serum Institut

In Vitro and In Vivo Efficacy of the Broad-Spectrum β-Lactamase Inhibitor APC24-7 in Combination with Meropenem Against Carbapenem-Resistant Enterobacterales

Background: Carbapenem-resistant Enterobacterales (CRE) represent a major therapeutic challenge, driven in part by serine β-lactamases (SBLs) and metallo-β-lactamases (MBLs). APC24-7 is a broad-spectrum β-lactamase inhibitor (BLI) designed to inhibit enzymes from both groups. Her...

Are fast test results preferable to high test sensitivity in contact-tracing strategies?

When an epidemic is spreading in a population, mitigation measures often rely on testing individuals, tracing possible secondary infections, and isolating known or suspected infected individuals. Because more accurate tests often take longer to analyse, and the benefits of contac...

Sexual and relational challenges in men and women affected by prostate cancer: a Project SEXUS study

OBJECTIVES: To examine, in a nationally representative Danish study, a comprehensive range of sexual characteristics, dysfunctions and relational challenges among men with prostate cancer (PCa) aged ≥50 years and women married to such men, compared with unaffected men and women....

Household consumer purchases and chronic disease

Chronic disease risk stratification remains costly and often provides limited insight into modifiable exposures. Consumer purchases are routinely generated, low-burden measures of household lifestyle that can be linked to health outcomes with consent. In this Danish cohort study,...

Association between p-tau181 in cerebrospinal fluid and shunt response in patients with normal-pressure hydrocephalus

Abstract Background Idiopathic normal pressure hydrocephalus (iNPH) is a treatable condition, but predicting shunt response remains challenging. Cerebrospinal fluid (CSF) biomarkers, including phosphorylated tau (p-tau181), have been suggested as potential predictors, although ex...

Postpartum Psychotropic Treatment Patterns and Breastfeeding: Nationwide Clustering Study

ABSTRACT Introduction Postpartum psychotropic medication use is heterogeneous, comprising continuation of prenatal treatment, initiation, transient use and complex polypharmacy. Prior studies have reported the prevalence of potential infant exposure to psychotropics via breast mi...

Bivalent RSV Prefusion F Vaccine to Prevent Hospitalizations in Adults

BACKGROUND: Respiratory syncytial virus (RSV) is an important cause of severe respiratory disease in adults, with the highest burden among older adults and individuals with chronic health conditions. The bivalent RSV prefusion F (RSVpreF) vaccine has been shown to prevent RSV-ass...

Durability of RSV Prefusion F Vaccine Protection across Two RSV Seasons

BACKGROUND: Respiratory syncytial virus (RSV) is an important cause of hospitalization and death among older adults. Although first-season vaccine effectiveness against RSV-related hospitalization has been demonstrated for the bivalent RSV prefusion F protein-based vaccine (RSVpr...

Variation in meningioma recurrence risk estimates across observational cohorts: the influence of calendar time, WHO classifications, geographical settings, and healthcare systems

Abstract Purpose Recurrence risk estimates underpin meningioma research, including molecular classification and clinical trial benchmarking, yet are often based on retrospective or historical data. The aim of this study was to assess the variation of recurrence risk estimates acr...

Urban heat vulnerability in a warming climate in Denmark: Projected temperature-related mortality for Copenhagen and the remaining areas

Objective We estimated future cold- and heat-related mortality for Copenhagen and remaining areas in Denmark under different warming scenarios. Methods We used nationwide historical and projected data on temperature, mortality, and population size. For 2000–2019, daily deaths wer...

Risk factors for tuberculosis: a nationwide cohort study among Greenlanders in Denmark, 2005–2022, highlighting social vulnerability

In tuberculosis (TB) low-incidence countries, TB is becoming increasingly concentrated in marginalised populations. Progress towards TB elimination therefore requires targeted interventions informed by knowledge on the determinants of disease in specific subpopulations. In Denmar...