State University of New York

Photo-Activatable RNA Switches for Optical Control of Cell-Free Protein Synthesis

Abstract Programmable RNA switches enable target-dependent regulation of cell-free protein synthesis. Here, we report a photo-activatable RNA switch using photocleavable Lock DNA (pcl-Lock) to enable optical control of in vitro translation. Synthesized by solid-phase methods, pcl...

Shifting Dominant Air Pollution Sources in Sub-Saharan Africa’s Changing Urban Environment: Analysis of Elemental Composition and Source Contributions of Ambient Fine Particulate Matter (PM2.5) Pollution in Accra, Ghana

Abstract Urban and economic expansion across Sub-Saharan Africa (SSA) may be shifting the relative contributions of dominant ambient air pollution sources, influencing both pollutant concentrations and composition, along with their associated health risks. However, city-scale dat...

A Rotary DNA Mazzocchio Nanostructure

Abstract DNA nanotechnology offers architectures ranging from compact motifs to scaffolded origami, with trade-offs in structural complexity, addressability, and component economy. Here, we translate Leonardo da Vinci’s mazzocchio geometry into a programmable DNA assembly. Twenty...

The silent pandemic: the overlooked toll of stroke compared to COVID-19

The COVID-19 pandemic will be remembered as one of the defining health crises of the modern era. The World Health Organization reported approximately 7 million deaths attributed to COVID-19 globall...

SpectralMol: Spectral Graph Bisection Achieves Universal Molecular Fragment Decomposition for Drug-Like Molecule Generation

Abstract Generating valid, diverse, and drug-like molecules remains a central challenge in computational drug discovery. A key bottleneck for fragment-based generative models is decomposition coverage: existing junction-tree methods fail on bridged bicyclic and spiro ring systems...

Postoperative Glycemic Deterioration and Outcomes After Total Knee Arthroplasty: Does It Matter?

Introduction: The prevalence of knee osteoarthritis and the annual incidence of total knee arthroplasty (TKA) continue to rise. A substantial proportion of TKA candidates have diabetes mellitus, which is associated with increased perioperative risk. Prior studies have largely foc...

Satellite based inference for disaster induced power outages using daily nighttime light observations

Abstract Power systems are vital to society, but remain vulnerable to natural disasters that cause widespread outages. Satellite-captured nightlights offer a global opportunity to monitor electricity disruptions. Prior work has typically relied on aggregating nightlight observati...

Plant Growth-Promoting Rhizobacteria as Sustainable Bioinoculants for Mitigating Climate-Induced Abiotic Stresses

Extreme temperatures, drought, and salinity are among the most detrimental abiotic stressors limiting global plant productivity, and their frequency has intensified under climate change. These escalating pressures underscore the need for sustainable biological strategies that enh...

Validity and Reliability of the Single-Item Flow Scale: An Initial Investigation

Flow is an experiential phenomenon that occurs when one is deeply engaged with an activity. The current set of studies aimed to create and test a single-item measure of flow for future use in studies where existing multi-item measures are not viable, such as exploratory research....

Tracking the baryon number with nuclear collisions

Baryon quantum number is found to be conserved since baryogenesis in the early Universe. Conventionally, each fractionally charged valence quark is understood to carry one-third of a baryon number. An alternative hypothesis posits that baryon number is instead carried by a baryon...

Fluorine-InducedElimination Drives Mechanism-BasedInactivation of Isocitrate Lyase

Abstract Fluorinated succinate analogues were evaluated as mechanistic probes of Mycobacterium tuberculosis isocitrate lyase (MtICL). However, 2,2-difluorosuccinate (1; Ki = 6.1 mM) and 2,2,3-trifluorosuccinate (2; Ki = 23.5 μM) act as reversible noncompetitive inhibitors and mes...

Circumventing thermodynamic limitations in converting carbon dioxide into carbon nanotubes via tandem catalysis

Carbon nanotubes (CNTs) are important materials for electronics and structural composites, but their production still relies on hydrocarbon-based chemical vapor deposition, an energy-intensive and fossil-dependent process, limited by rapid catalyst deactivation. Using CO 2 as a c...