State Research Institute Centre for Innovative Medicine

Mitochondrial Modulation as a Therapeutic Entry Point in Neurodegeneration

Mitochondrial dysfunction is a recurrent but context-dependent feature of neurodegenerative disease, and its position in the pathogenic cascade differs fundamentally between disorders. This narrative review argues that this heterogeneity, rather than mitochondrial biology itself,...

Thiram Disrupts Hepatic and Tibial Calcium Homeostasis via ER Stress‐Mediated IP3R1 / VDAC1 Hyperactivation

ABSTRACT Thiram is an agricultural fungicide known to disrupt cellular calcium homeostasis by inducing endoplasmic reticulum (ER) stress and mitochondrial calcium overload in hepatic and growth plate (GP) tissues. Current study investigated thiram‐induced alterations at mitochond...