State Key Laboratory of Synthetic Chemistry

Full-Range Ultrasensitive Fiber-Optic Hydrogen Detection via Twin Vernier Amplification and Lightweight CNN

Reliable hydrogen monitoring requires sensors that combine high sensitivity, wide dynamic range, and resistance to environmental interference. Here, we report a monolithically integrated dual-Fabry-Pérot interferometer (dual-FPI) fiber-optic hydrogen sensor that couples twin Vern...

Chemo-Enzymatic Synthesisof Purine 3′-O-Amino-DeoxyribonucleosideTriphosphates

Abstract 3′-O-amino-deoxyribonucleoside triphosphates (3′-ONH2-dNTPs) are crucial reversible terminators for template-independent DNA synthesis. Owing to the structural complexity of purine bases, here we propose a chemo-enzymatic process for the synthesis of purine-type 3′-ONH2-...

p38β-mediated BiP phosphorylation drives stemness and chemoresistance by suppressing UPR activation in hepatocellular carcinoma

Abstract Tumor-initiating cells (TICs) promote tumor initiation and therapy resistance, yet the kinase regulators that sustain TICs remain incompletely defined. Here, we identify the stress kinase p38β (MAPK11) supports TIC maintenance and drug resistance in hepatocellular carcin...