State Key Laboratory of Synthetic Chemistry

Electrochemical Control of Scholl Reaction: Arenium Cation Versus Radical Cation Pathways

ABSTRACT The Scholl reaction is a cornerstone method for constructing polycyclic aromatic hydrocarbons, yet its mechanism remains highly debated because arenium and radical cation intermediates are difficult to characterize. Herein, we demonstrate that electrochemical oxidation p...

Biocatalytic Synthesis of dNTPs from Bacterial Biomass

Abstract Deoxyribonucleoside triphosphates (dNTPs) are crucial reagents widely utilized in nucleic acid amplification. However, current synthesis methods are often plagued by environmental pollution for chemical synthesis and the high costs of phosphate donors for enzymatic synth...

Synergistic Carbocation Quenching and Bioprotective Shielding for Uncondensed Lignin and In Situ Saccharification

Abstract The “lignin-first” biorefinery using deep eutectic solvents (DESs) offers a promising route to valorize lignocellulose, yet conventional acidic DESs suffer from severe lignin condensation and cellulase incompatibility, necessitating energy-intensive washing steps. Herein...

Ori-Finder-Arch: An Updated Web Server for the Annotation and Visualization of Archaeal Replication Origins

Abstract Archaea are promising chassis organisms in biotechnology, and the accurate annotation of their chromosomal replication origins (oriCs) is the key to unlocking their full potential. However, the existing Ori-Finder 2 web server suffers from low accuracy, slow speed, and l...

Suppression of Peierls Instability in a Metal−Halide Porous Framework

ABSTRACT Peierls distortion is a lattice instability in low‐dimensional materials driven by electron–phonon coupling, which opens an energy gap at the Fermi level and induces a metal–insulator transition. Suppressing this distortion is crucial for stabilizing metallic and superco...

Suppression of Peierls Instability in a Metal−Halide Porous Framework

ABSTRACT Peierls distortion is a lattice instability in low‐dimensional materials driven by electron–phonon coupling, which opens an energy gap at the Fermi level and induces a metal–insulator transition. Suppressing this distortion is crucial for stabilizing metallic and superco...

Full-Range Ultrasensitive Fiber-Optic Hydrogen Detection via Twin Vernier Amplification and Lightweight CNN

Reliable hydrogen monitoring requires sensors that combine high sensitivity, wide dynamic range, and resistance to environmental interference. Here, we report a monolithically integrated dual-Fabry-Pérot interferometer (dual-FPI) fiber-optic hydrogen sensor that couples twin Vern...

Chemo-Enzymatic Synthesisof Purine 3′-O-Amino-DeoxyribonucleosideTriphosphates

Abstract 3′-O-amino-deoxyribonucleoside triphosphates (3′-ONH2-dNTPs) are crucial reversible terminators for template-independent DNA synthesis. Owing to the structural complexity of purine bases, here we propose a chemo-enzymatic process for the synthesis of purine-type 3′-ONH2-...

p38β-mediated BiP phosphorylation drives stemness and chemoresistance by suppressing UPR activation in hepatocellular carcinoma

Abstract Tumor-initiating cells (TICs) promote tumor initiation and therapy resistance, yet the kinase regulators that sustain TICs remain incompletely defined. Here, we identify the stress kinase p38β (MAPK11) supports TIC maintenance and drug resistance in hepatocellular carcin...