State Key Laboratory of Polymer Physics and Chemistry

Dynamic Covalent Prodrug Nanocomplex for Ultrasound‐Triggered Oxidative Stress Amplification and Synergistic Sonochemotherapy

ABSTRACT Essential micronutrient Vitamin B 2 (VB 2 ) is a bioactive compound with sonodynamic activity; however, it suffers from hydrophilic limitations. Herein, a dynamic prodrug nanocomplex (PTX‐PBA/VB 2 ) was constructed via phenylboronic acid‐diol interaction between VB 2 and...

Raman Self‐Tracking Copper Metal‐Organic Framework‐Based Nanoplatform for Cuproptosis Cancer Therapy

ABSTRACT Cuproptosis represents a promising strategy for cancer therapy, yet its clinical translation is hampered by unexpected deactivation and off‐target toxicity of copper ions during their delivery to tumors. We developed a copper metal‐organic framework‐based nanoplatform (C...

Cationic Amphiphilic Polypeptides With Immunogenic Cell Death Inducing Activity for Inhibition of Metastatic Bone Cancer

Immunogenic cell death (ICD)-mediated activation of antitumor immunity is being explored as a therapeutic approach for cancers with bone metastasis. In this study, several cationic amphiphilic polypeptides were obtained to investigate their architecture-dependent cytotoxicity and...

Calcium dysregulation in synergy with sonodynamic therapy via medroxyprogesterone-targeted and ROS-responsive nanoparticles for endometrial cancer

Effective therapies that enable precise drug delivery and integrated monitoring are urgently needed for fertility-sparing management of endometrial cancer (EC). Although calcium channel blockers (CCBs) exhibit anti-proliferative potential in EC, their poor tumor selectivity and s...

Solution‐Processed Perhydropolysilazane for Advanced Silica Coatings: From Conversion Mechanisms to Next‐Generation Device Integration

ABSTRACT Perhydropolysilazane (PHPS) provides a unique solution‐based route for fabricating silica coatings through the direct conversion of an inorganic polymer precursor into an amorphous Si–O–Si network. Unlike conventional sol–gel systems, PHPS forms silica through the transf...

Integrating Cation Disordering With Surface Tailoring via Sn/In Co‐Doping for High‐Performance Perovskite Cathode

ABSTRACT The development of stable, durable cathodes with high oxygen reduction reaction (ORR) activity remains a critical challenge in solid oxide fuel cell (SOFC) research. This work employs a Sn‐In co‐doping strategy to synthesize a cathode material with the nominal compositio...

A Poly(lactic Acid)‐Porphyrin‐Cobalt Vaccine Adjuvant System Elicits Protein‐ or Peptide‐Specific Humoral and Cellular Immunity

ABSTRACT There is growing interest in vaccine adjuvant systems that are scalable, adaptable, and capable of stimulating humoral and cellular immune responses with recombinant protein or synthetic peptide immunogens. In this study, we introduced a “plug‐and‐play” nanoadjuvant syst...

Ultrahigh-sensitivity adaptive solar-blind organic neuromorphic sensors for robust corona discharge monitoring

Abstract Low‑cost and high‑efficiency corona-discharge detection is essential for safe high‑voltage transmission operation, yet state‑of‑the‑art solar‑blind ultraviolet (SBUV) photodetectors for corona monitoring suffer from insufficient sensitivity, poor stability and weak anti‑...

Immunomodulatory, Antibacterial, Antioxidative and EGF‐Delivering Hydrogel Remodels Wound Microenvironment for Infected Diabetic Wound Healing

ABSTRACT The treatment of diabetic wounds remains a major challenge due to persistent bacterial infections, chronic inflammation, and impaired angiogenesis. To address these issues, we develop an immunomodulatory and antibacterial hydrogel integrating epidermal growth factor (EGF...

A Chloroplast-Inspired Theranostic Nanoplatform for Self-Sustaining Oxygen-Elevating Photodynamic Therapy and Glutathione-Triggered Carbon-Centered Radical Synergistic Therapy

Achieving precise drug delivery to the tumor site can minimize systemic side effects caused by off-target effects. As a therapy that depends on oxygen content, photodynamic therapy (PDT) is significantly constrained by the hypoxic nature of the tumor microenvironment (TME). Compa...

Chlorine Radical Mediated Tandem Dehydrogenation–Oxidation for Upcycling Polyolefins to Functional Wax at Low Temperature in Air

ABSTRACT Polyolefins valued for their excellent properties are the highest produced and widely used plastics. However, their chemical stability and massive accumulation arouse severe environmental issues, necessitating urgent resolution of recycling. Current recycling strategies...