State Key Laboratory of Oncology in South China

Targeting MDA5 induces immunogenic cell death and promotes anti-tumor immunity

Identifying targets to enhance tumor immunity is an urgent need. Although nucleic acid sensors play critical roles in promoting tumor immune clearance, their exceptionally low mutation rate in cancers suggests potential unexplored roles in tumor progression. Here, we demonstrate...

Single-nucleus transcriptomics reveals an early-relapse-associated epithelial–myeloid–T cell niche in advanced high-grade serous ovarian cancer

Early relapse remains a major clinical challenge in advanced HGSOC, but the tumor microenvironmental features associated with relapse timing remain poorly defined. Here, we performed snRNA-seq on treatment-naive tumors from patients with advanced HGSOC, including STDFS ( n = 4) a...

IL10RB-AS1 promotes pro-caspase-1-dependent pyroptosis via regulating the oligomerization and nucleation of CARD8 C-terminal domain to suppress acute myeloid leukemia

Abstract CARD8 (caspase activation and recruitment domain-containing 8) senses intracellular danger signals, leading to inflammasome formation and pyroptosis. Recently studies have shown that CARD8 was highly expressed in hematopoietic cells, however, the mechanism by which the r...