State Key Laboratory of Oncogene and Related Genes

Characterization of SPP1 + macrophages and their correlation with resistance to neoadjuvant chemotherapy in colorectal cancer liver metastasis

Neoadjuvant chemotherapy (NAC) for colorectal cancer liver metastasis (CRLM) remains a major clinical challenge, with outcomes varying widely among patients, yet the mechanisms that drive therapeutic resistance remain incompletely understood. In this study, we integrated single‑c...

Effectiveness of anti-TNF therapy after prior ustekinumab exposure in Crohn’s disease: A propensity-weighted cohort study

Abstract Background As ustekinumab is increasingly used earlier in Crohn’s disease (CD), evidence regarding the effectiveness of subsequent anti-tumor necrosis factor (TNF) therapy remains limited. We compared anti-TNF outcomes after prior ustekinumab exposure with first-line ant...

Longitudinal profiling of urinary extracellular vesicle RNA reveals physiological variability and stable reference genes in healthy individuals

Urinary extracellular vesicles (uEVs) have emerged as promising non-invasive molecular carriers for biomarker discovery, yet the physiological variability and tissue-associated characteristics of uEV RNA cargo in healthy individuals remain poorly defined. This knowledge gap limit...

A programmed sequential organelle-targeted nanoattack strategy for cGAS-STING hyperactivation and potentiated systemic cancer immunotherapy

Cancer immunotherapy is hindered by insufficient immunogenic cell death (ICD) and suboptimal cGAS-STING activation. While organelle-targeted therapies hold promise, conventional treatments often fail because single-target attacks are neutralized by tumor buffering networks, where...

Changing trends in the clinical characteristics of gastrointestinal bleeding among hospitalized patients from 2012-2024 in China: a retrospective study

Gastrointestinal bleeding (GIB) remains a critical medical emergency with rising healthcare burdens in China. This study aimed to analyze its epidemiological shifts and risk factors over the past decade. A retrospective analysis included 3,523 inpatients with GIB at Renji Hospita...

Targeting the ANKRD54/ELOVL6 axis suppresses malignancy in BRAF mutant colorectal cancer by disrupting fatty acid metabolism and promoting ferroptosis

Abstract Background BRAF-mutant (BRAF-MT) colorectal cancer (CRC) represents a clinically aggressive subtype characterized by distinct biological features and significantly worse prognosis compared to BRAF wild-type (BRAF-WT) CRC, with median survival reduced by approximately 40%...