State Key Laboratory of Natural Medicine

Astragaloside IV improves MASLD via GCN5-LXRα/SREBP1c signaling pathway-mediated hepatic de novo lipogenesis

BACKGROUND: Astragaloside IV (AS-IV), a bioactive saponin from Astragalus membranaceus, shows promise for treating metabolic dysfunction-associated steatotic liver disease (MASLD), though its mechanisms remain unclear. PURPOSE: This study aimed to elucidate how AS-IV alleviates h...

Pharmacological inhibition of Alistipes putredinis-derived indole-3-acetic acid by baicalin suppresses stress-driven breast cancer metastasis

Breast cancer patients often experience chronic stress disorders and gut dysbiosis. Baicalin has been demonstrated to have antitumor, antibacterial and microbiota regulatory functions and can be used for treating breast cancer and preventing metastasis; however, how baicalin regu...