State Key Laboratory of Digital Medical Engineering

A unified mechano-ionic skin for resolving native electromechanical coupling

The beat-to-beat electromechanical coupling between cardiac excitation and arterial pulse propagation encodes vital cardiovascular insights, but resolving this coherence in wearables is hindered by the spatial decoupling of sensors and attenuated epidermal signals. Here, we repor...

Recent Advances in Two‐Photon Lithography of 3D Inorganic Microstructures: Glass, Ceramics, Metals, and Carbon

The fabrication of intricate three-dimensional (3D) inorganic microstructures - including glass, ceramics, metals, and carbon - is essential for next-generation devices in MEMS, photonics, energy storage, and biointerfaces. However, simultaneously achieving sub-micron resolution,...

Structure-based design of peptide inhibitors targeting the SPSB2–iNOS interaction: a computational approach to modulating nitric oxide signaling

Dysregulation of inducible nitric oxide synthase (iNOS) plays a central role in inflammatory diseases, cancer, and neurodegeneration due to excessive nitric oxide (NO) production. Suppressor of Cytokine Signaling Box Protein 2 (SPSB2) is a key negative regulator of iNOS through s...