State Key Laboratory of Diagnosis and Treatment of Infectious Diseases

Functional mapping of IFITM3 resolves its antiviral core and deciphers human influenza susceptibility

Genetic variation in interferon-induced transmembrane protein 3 (IFITM3) contributes to inter-individual differences in influenza outcome, yet a comprehensive functional map of IFITM3 variation remains unavailable. Here we show a high-resolution functional atlas of 2,898 IFITM3 v...