State Key Laboratory of Biotherapy

Molecular basis of PADI6 species-specific oligomerization in maternal regulatory complexes

Peptidyl arginine deiminase 6 (PADI6) is an essential maternal effector in mammalian oocytes and preimplantation embryos. Recently, we identified the conserved maternal PADI6-UHRF1-UBE2D complex (MPU). MPU, together with the subcortical maternal complex (SCMC), further forms the...

Tumor-associated CALD1 splicing variant driven by hnRNPA1 promotes colorectal cancer metastasis

Alternative splicing (AS) expands transcriptomic and proteomic diversity and is increasingly implicated in colorectal cancer (CRC) progression, yet the functional relevance of individual AS isoforms and the splicing regulators directing their generation remain poorly understood....

Ocular Gene Therapy in China: Technological Framework, Clinical Translation, and Future Perspectives

The eye is well suited to gene therapy because of its compartmentalized anatomy, accessibility for local delivery, and capacity for longitudinal assessment. In China, ocular gene therapy is undergoing rapid clinical translation, with expanding innovation in vector engineering, de...

Next-generation natural killer cell therapy: bench to bedside and beyond

Natural killer (NK) cells have emerged as central players in cancer immunotherapy, progressing from basic discovery to clinically validated platforms over five decades. This review synthesizes the evolving understanding of NK cell biology, including subset heterogeneity, epigenet...

Intratumoral microbiota: spatiotemporal dynamics, microenvironmental immune reprogramming, and immunotherapeutic implications

The discovery of intratumoral microbiota has challenged the traditional view of tumors as sterile environments and revealed a previously unrecognized layer of complexity within the tumor microenvironment (TME). Accumulating evidence indicates that microorganisms residing in tumor...

Modified Xiaoyaosan Regulates the Neuro-Immune Microenvironment in Chronic Stress: A Preclinical Meta-Analysis and NF-kappaB Pathway Mechanism Exploration

Background: Chronic unpredictable mild stress (CUMS) triggers systemic pathologies, notably depression and endocrine disorders such as hyperprolactinemia (HPRL). Xiaoyaosan (XYS), a classic traditional Chinese medicine formulation, has been proven effective in treating these stre...

Ultrasound-defined hepatic steatosis and clustering of cardiometabolic abnormalities: endpoint-dependent performance of seven metabolic indices in 356,197 adults

Hepatic steatosis commonly coexists with cardiometabolic abnormalities, but the extent to which an ultrasound finding identifies their clustering in routine health-examination populations remains unclear. We quantified the association between hepatic steatosis and cardiometabolic...

UA-30 ameliorates motor deficits through RalA-mediated mitophagy in ALS mice

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive motor neuron loss, skeletal muscle atrophy, paralysis, and eventually death. Mitochondrial dysfunction plays a pivotal role in ALS pathogenesis, although the precise pathogenic mechani...

Efficient Colon Cancer Immunogene Therapy by Hydrogel Ball Loaded With Two Types of Cell Membrane‐Coated Nanoparticles

ABSTRACT Biomimetic technology has high potential for enhancing cancer immunogene therapy. Cell membrane‐coated nanoparticles (CMNPs) obtain extra targeting, recognition, and signaling transduction functions. However, a single kind of CMNPs is limited when facing complicated tumo...

Mechanistic basis of LolDF-mediated lipoprotein transport in Acinetobacter

Lipoprotein trafficking is essential for Gram-negative bacteria to maintain the outer membrane, a permeability barrier critical for survival and antibiotic resistance. While most bacteria employ the canonical LolCDE transporter, Acinetobacter utilizes a noncanonical LolDF system...