State Administration of Traditional Chinese Medicine of the People's Republic of China

SHP2 accelerated acute liver injury via modulating TGFβ1/EZH2/BRD4 signaling induced proliferation and fibrosis of HSC

To explore the specific molecular mechanisms by which SHP2 promotes liver injury. Single-cell transcriptomics and bioinformatics analyses were employed for predictive screening. C57BL/6J mice were assigned to normal, model, and model+PHPS1 groups. Liver injury and fibrosis were e...

Divergent Synthesis of Functionalized Spiroindanediones via CdI2/MgI2-Catalyzed Multiple Cyclocondensation Modes

Abstract Divergent synthesis enables rapid construction of structurally diverse compound libraries from the same universal substrates and is a current research hotspot. Here, the self-(3 + 2), (2 + 1), and (1 + 1 + 1) cyclocondensations of 2-arylidene-1,3-indanediones 1 were real...