State Administration of Traditional Chinese Medicine of the People's Republic of China

Isoliquiritigenin Triggers HMOX1-Driven Ferroptosis to Suppress Non-Small Cell Lung Cancer

Non-small cell lung cancer (NSCLC) remains the leading cause of cancer-related death, and new treatment strategies are needed. Ferroptosis is an iron-dependent cell death driven by lipid peroxidation, and targeting ferroptosis has become a new strategy for anti-NSCLC. Isoliquirit...

DNA Barcoding for Identification and Traceability in the Entire Industrial Chain of Lonicerae Japonicae Flos

As a traditional medicinal plant in China, Lonicerae Japonicae Flos (LJF) is extensively used in traditional Chinese medicine and Medicine Food Homology products, supporting a well-established industrial chain with diverse applications. However, the entire industrial chain is per...

Structural characterization of an RG-II-associated complex pectic polysaccharide from Typha angustifolia pollen with dendritic cell-modulating activity

BACKGROUND: Pectic polysaccharides from medicinal plants are promising natural immunomodulators, but their structural heterogeneity has hindered the identification of bioactive domains and limited their further development. The structural basis underlying their regulation of dend...

High tibial osteotomy for proximal tibial osteonecrosis with medial tibial plateau fracture in a patient with prior knee arthroscopy: a case report

High tibial osteotomy (HTO) is a well-established joint-preserving procedure for unloading the medial compartment of the knee. It has been applied in selected cases of spontaneous osteonecrosis or subchondral insufficiency fracture of the knee. However, the coexistence of proxima...

FuTCM-PDD: a multi-level information fusion framework integrating KAN modeling and AutoML for phenotype-based drug discovery from Traditional Chinese Medicine

Phenotype-based drug discovery has attracted increasing attention due to its critical role in first-in-class drug development and higher clinical translation rates. Chinese Materia Medica (CMM), with its emphasis on properties and efficacies, provides a unique framework for pheno...

Engineered Mitochondria-Targeted Biomimetic Hybrid Nanovesicles Ameliorate Rheumatoid Arthritis via Regulating Macrophage Autophagy and cGAS-STING Signaling

Abstract Despite decades of intensive investigation, rheumatoid arthritis (RA) remains a therapeutic challenge, primarily attributed to its intricate pathological microenvironment and poorly elucidated etiology. However, mitochondrial dysfunction and abnormal activation of the cG...

Rapid Identification of Multiple Types of Adulterated Ophiocordyceps sinensis by SEM ‐ EDS Based on Micromorphology and Elemental Analysis

As a rare and precious traditional Chinese medicine (TCM), Ophiocordyceps sinensis (O. sinensis) is plagued by various adulterants in the market due to factors such as resource scarcity, which seriously affects medication safety and clinical efficacy. Existing identification meth...

SLC7A11-associated astrocyte states are linked to redox imbalance and synaptic microenvironment remodeling in multiple sclerosis: translational implications

Abstract Background Multiple sclerosis (MS) is characterized by inflammatory demyelination, oxidative stress, and neurological dysfunction. Despite disease-modifying therapies, chronic active lesions and ongoing neurodegeneration remain largely untreated, highlighting the need fo...

Merging artificial intelligence and retinal vascular geometric parameters: A novel tool for diagnosis and prognosis prediction of diabetic nephropathy

Abstract Background: Diabetic nephropathy (DN) is the leading cause of end-stage renal disease. The retinal microvasculature, as the only directly observable microvasculature, may reflect DN progression. This study aims to construct a non-invasive diagnostic and prognostic predic...

SHP2 accelerated acute liver injury via modulating TGFβ1/EZH2/BRD4 signaling induced proliferation and fibrosis of HSC

To explore the specific molecular mechanisms by which SHP2 promotes liver injury. Single-cell transcriptomics and bioinformatics analyses were employed for predictive screening. C57BL/6J mice were assigned to normal, model, and model+PHPS1 groups. Liver injury and fibrosis were e...

Divergent Synthesis of Functionalized Spiroindanediones via CdI2/MgI2-Catalyzed Multiple Cyclocondensation Modes

Abstract Divergent synthesis enables rapid construction of structurally diverse compound libraries from the same universal substrates and is a current research hotspot. Here, the self-(3 + 2), (2 + 1), and (1 + 1 + 1) cyclocondensations of 2-arylidene-1,3-indanediones 1 were real...